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Practical guidance for clinical laboratories for SARS-CoV-2 serology testing.
Charlton, Carmen; Kanji, Jamil; Tran, Vanessa; Kus, Julianne; Gubbay, Jonathan; Osiowy, Carla; Robinson, Jason; Sekirov, Inna; Drebot, Michael; Hatchette, Todd; Stein, Derek; El-Gabalawy, Nadia; Lang, Amanda; Jiao, Lei; Levett, Paul; Wood, Heidi; Therrien, Christian; Lindsay, L Robbin; Morshed, Muhammad; Forbes, Jessica; Dibernardo, Antonia.
  • Charlton C; Public Health Laboratory, Alberta Precision Laboratories, Edmonton, AB.
  • Kanji J; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB.
  • Tran V; Li Ka Shing Institute of Virology, Edmonton, AB.
  • Kus J; Public Health Laboratory, Alberta Precision Laboratories, Edmonton, AB.
  • Gubbay J; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB.
  • Osiowy C; Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, AB.
  • Robinson J; Public Health Ontario Laboratory, Toronto, ON.
  • Sekirov I; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON.
  • Drebot M; Public Health Ontario Laboratory, Toronto, ON.
  • Hatchette T; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON.
  • Stein D; Public Health Ontario Laboratory, Toronto, ON.
  • El-Gabalawy N; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON.
  • Lang A; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.
  • Jiao L; Provincial Laboratory Services, Division of Clinical Chemistry, Health PEI, Charlottetown, PE.
  • Levett P; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, BC.
  • Wood H; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.
  • Therrien C; Newfoundland and Labrador Public Health Microbiology Laboratory, St. John's, NL.
  • Lindsay LR; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB.
  • Morshed M; Cadham Provincial Laboratory, Winnipeg, MB.
  • Forbes J; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.
  • Dibernardo A; Roy Romanow Provincial Laboratory, Regina, SK.
Can Commun Dis Rep ; 47(4): 171-183, 2021 May 07.
Article in English | MEDLINE | ID: covidwho-1244370
ABSTRACT
The landscape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic testing is rapidly evolving. While serology testing has limited diagnostic capacity for acute infection, its role in providing population-based information on positivity rates and informing evidence-based decision making for public health recommendations is increasing. With the global availability of vaccines, there is increasing pressure on clinical laboratories to provide antibody screening and result interpretation for vaccinated and non-vaccinated individuals. Here we present the most up-to-date data on SARS-CoV-2 antibody timelines, including the longevity of antibodies, and the production and detection of neutralizing antibodies. Additionally, we provide practical guidance for clinical microbiology laboratories to both verify commercial serology assays and choose appropriate testing algorithms for their local populations.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Topics: Vaccines Language: English Journal: Can Commun Dis Rep Journal subject: Communicable Diseases / Epidemiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Topics: Vaccines Language: English Journal: Can Commun Dis Rep Journal subject: Communicable Diseases / Epidemiology Year: 2021 Document Type: Article