Your browser doesn't support javascript.
Elevated HbA1c levels in pre-Covid-19 infection increases the risk of mortality: A sistematic review and meta-analysis.
Prattichizzo, Francesco; de Candia, Paola; Nicolucci, Antonio; Ceriello, Antonio.
  • Prattichizzo F; IRCCS MultiMedica, Milan, Italy.
  • de Candia P; IRCCS MultiMedica, Milan, Italy.
  • Nicolucci A; Centre for Outcomes Research and Clinical Epidemiology (CORESEARCH), Pescara, Italy.
  • Ceriello A; IRCCS MultiMedica, Milan, Italy.
Diabetes Metab Res Rev ; 38(1): e3476, 2022 01.
Article in English | MEDLINE | ID: covidwho-1245386
Semantic information from SemMedBD (by NLM)
1. Diabetes PROCESS_OF Patients
Subject
Diabetes
Predicate
PROCESS_OF
Object
Patients
2. Worse PROCESS_OF Patients
Subject
Worse
Predicate
PROCESS_OF
Object
Patients
3. Increased risk PROCESS_OF Patients
Subject
Increased risk
Predicate
PROCESS_OF
Object
Patients
4. Poor glycemic control PROCESS_OF Patients
Subject
Poor glycemic control
Predicate
PROCESS_OF
Object
Patients
5. Diabetes PROCESS_OF Patients
Subject
Diabetes
Predicate
PROCESS_OF
Object
Patients
6. Worse PROCESS_OF Patients
Subject
Worse
Predicate
PROCESS_OF
Object
Patients
7. Increased risk PROCESS_OF Patients
Subject
Increased risk
Predicate
PROCESS_OF
Object
Patients
8. Poor glycemic control PROCESS_OF Patients
Subject
Poor glycemic control
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

AIMS:

Diabetes is emerging as a risk factor for coronavirus disease (COVID)-19 prognosis. However, contradictory findings have been reported regarding the impact of glycaemic control on COVID-19 outcome. The aim of this meta-analysis was to explore the impact of hospital pre-admission or at-admission values of HbA1c on COVID-19 mortality or worsening in patients with diabetes. MATERIALS AND

METHODS:

We searched PubMed, Embase and Scopus up to 30th December 2020. Eligibility criteria for study selection were the following (1)enrolling patients with any form of diabetes mellitus and hospitalized for COVID-19 and (2) reporting data regarding HbA1c values before infection or at hospital admission in relation to COVID-19 mortality or worsening. Descriptive statistics, HbA1c values, odds ratios (ORs) and hazard ratios were extracted from seven observational studies and generic inverse variance (random effects) of OR was used to estimate the effect of HbA1c on COVID-19 outcome.

RESULTS:

HbA1c was linearly associated with an increased COVID-19 mortality or worsening when considered as a continuous variable (OR 1.01 [1.01, 1.01]; p < 0.00001). Similarly, when analysing studies providing the number of events according to the degree of glycaemic control among various strata, a significantly increased risk was observed with poor glycaemic control (OR 1.15 [1.11, 1.19]; p < 0.00001), a result corroborated by sensitivity analysis.

CONCLUSIONS:

Notwithstanding the large heterogeneity in study design and patients' characteristics in the few available studies, data suggest that patients with diabetes and poor glycaemic control before infection might have an increased risk of COVID-19 related mortality.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Glycated Hemoglobin A / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Diabetes Metab Res Rev Journal subject: Endocrinology / Metabolism Year: 2022 Document Type: Article Affiliation country: Dmrr.3476

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Glycated Hemoglobin A / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Diabetes Metab Res Rev Journal subject: Endocrinology / Metabolism Year: 2022 Document Type: Article Affiliation country: Dmrr.3476