Chitosan, alginate, hyaluronic acid, gums, and ß-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review.
Int J Biol Macromol
; 182: 1931-1940, 2021 Jul 01.
Article
in English
| MEDLINE | ID: covidwho-1245965
ABSTRACT
Pathogen transmission is a widespread threat to global human health. Vaccines are very important during the outbreak of a pandemic. Destructive fractures caused by a sudden outbreak of COVID-19 have spurred vaccine production at an unprecedented rate. The strategy of an effective vaccine delivery system is opening up novel probabilities to make more immunization. Indeed, vaccination is the most successful way to prevent deaths from infectious diseases. In order to optimal immune response production or improvement in the effectiveness of vaccines, delivery systems or adjuvants are required. Natural polymers such as chitosan, alginate, hyaluronic acid, gums, and ß-glucan with antiviral activity have good potential as adjuvant or delivery systems for vaccine formulation development and design vaccine delivery devices. According to the antiviral performance and immunomodulation of these biopolymers, they will play significant characters in the anti-COVID-19 field. In this mini-review, the recent progress in vaccine development by using biopolymers is presented which, provides a reference for their research on anti-COVID-19 drugs and vaccines.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Adjuvants, Immunologic
/
Drug Delivery Systems
/
Chitosan
/
Beta-Glucans
/
Alginates
/
Plant Gums
/
COVID-19 Vaccines
/
SARS-CoV-2
/
COVID-19
/
Hyaluronic Acid
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Int J Biol Macromol
Year:
2021
Document Type:
Article
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