Successful Salvage Haploidentical Bone Marrow Transplantation in a Child With Hemophagocytic Lymphohistiocytosis, When the Previously Matched Unrelated Donor Tested Positive for SARS-CoV-2 on the Day of Stem Cells Collection.
Transplant Proc
; 53(8): 2498-2501, 2021 Oct.
Article
in English
| MEDLINE | ID: covidwho-1246217
ABSTRACT
The coronavirus disease 2019 pandemic has made us adjust our standards and cope with unpredictable circumstances affecting the whole world, including the medical field. A 2-year-old boy diagnosed with X-linked lymphoproliferative disease type 2 with concomitant positive polymerase chain reaction test for Epstein-Barr virus-DNA was admitted to our transplant ward. His treatment scheme had to be modified at the last moment because of a donor disqualification due to a positive polymerase chain reaction result for severe acute respiratory syndrome coronavirus 2 just before the apheresis. We decided to perform salvage haploidentical bone marrow transplant from the patient's mother because it was the only possible option. Now, in a 5-month observation period after the hematopoietic stem cell transplantation, our patient is in good general condition. His case convinced us to redirect our approach to transplant procedure preparation. Following the European Group of Blood and Marrow Transplantation recommendations, we use cryopreserved apheresis materials to ensure the availability of stem cell products before the start of a conditioning regimen.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Bone Marrow Transplantation
/
Salvage Therapy
/
Hematopoietic Stem Cell Transplantation
/
Epstein-Barr Virus Infections
/
Lymphohistiocytosis, Hemophagocytic
/
COVID-19
Type of study:
Case report
/
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Child, preschool
/
Humans
/
Male
Language:
English
Journal:
Transplant Proc
Year:
2021
Document Type:
Article
Affiliation country:
J.transproceed.2021.04.017
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