Natural coumarins as potential anti-SARS-CoV-2 agents supported by docking analysis.
RSC Adv
; 11(28): 16970-16979, 2021 May 06.
Article
in English
| MEDLINE | ID: covidwho-1246407
ABSTRACT
COVID-19 is a global pandemic first identified in China, causing severe acute respiratory syndrome. One of the therapeutic strategies for combating viral infections is the search for viral spike proteins as attachment inhibitors among natural compounds using molecular docking. This review aims at shedding light on the antiviral potential of natural products belonging to the natural-products class of coumarins up to 2020. Moreover, all these compounds were filtered based on ADME analysis to determine their physicochemical properties, and the best 74 compounds were selected. Using virtual-screening methods, the selected compounds were investigated for potential inhibition of viral main protease (Mpro), viral methyltransferase (nsp16/10 complex), viral recognition binding domain (RBD) of S-protein, and human angiotensin-converting enzyme 2 (ACE2), which is the human receptor for viral S-protein targets, using molecular-docking studies. Promising potential results against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and methyltransferase (nsp16) are presented.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
RSC Adv
Year:
2021
Document Type:
Article
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