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Coronavirus disease 2019 (COVID-19) Versus Influenza in Hospitalized Adult Patients in the United States: Differences in Demographic and Severity Indicators.
Talbot, H Keipp; Martin, Emily T; Gaglani, Manjusha; Middleton, Donald B; Ghamande, Shekhar; Silveira, Fernanda P; Murthy, Kempapura; Zimmerman, Richard K; Trabue, Christopher H; Olson, Samantha M; Petrie, Joshua G; Ferdinands, Jill M; Patel, Manish M; Monto, Arnold S.
  • Talbot HK; Department of Medicine and Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Martin ET; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Gaglani M; Baylor Scott & White Health, Texas A&M University College of Medicine, Temple, Texas, USA.
  • Middleton DB; Department of Medical Education at Texas A&M University COM, Texas, USA.
  • Ghamande S; Department of Medicine, Division of Infectious Diseases, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Silveira FP; Baylor Scott & White Health, Texas A&M University College of Medicine, Temple, Texas, USA.
  • Murthy K; Department of Medical Education at Texas A&M University COM, Texas, USA.
  • Zimmerman RK; Department of Medicine, Division of Infectious Diseases, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Trabue CH; Baylor Scott & White Health, Texas A&M University College of Medicine, Temple, Texas, USA.
  • Olson SM; Department of Medicine, Division of Infectious Diseases, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Petrie JG; Department of Medicine, University of Tennessee Health Science Center, Saint Thomas Health, Nashville, Tennessee, USA.
  • Ferdinands JM; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Patel MM; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Monto AS; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
Clin Infect Dis ; 73(12): 2240-2247, 2021 12 16.
Article in English | MEDLINE | ID: covidwho-1246699
Semantic information from SemMedBD (by NLM)
1. Influenza PROCESS_OF hospitalized patients
Subject
Influenza
Predicate
PROCESS_OF
Object
hospitalized patients
2. Patient in hospital PROCESS_OF Adult
Subject
Patient in hospital
Predicate
PROCESS_OF
Object
Adult
3. Influenza PROCESS_OF Adult
Subject
Influenza
Predicate
PROCESS_OF
Object
Adult
4. Influenza PROCESS_OF Patients
Subject
Influenza
Predicate
PROCESS_OF
Object
Patients
5. COVID-19 CAUSES Influenza
Subject
COVID-19
Predicate
CAUSES
Object
Influenza
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. COVID-19 OCCURS_IN Patients
Subject
COVID-19
Predicate
OCCURS_IN
Object
Patients
8. Complication COEXISTS_WITH COVID-19
Subject
Complication
Predicate
COEXISTS_WITH
Object
COVID-19
9. Hospital admission TREATS Discharged Alive
Subject
Hospital admission
Predicate
TREATS
Object
Discharged Alive
10. Influenza PROCESS_OF hospitalized patients
Subject
Influenza
Predicate
PROCESS_OF
Object
hospitalized patients
11. Patient in hospital PROCESS_OF Adult
Subject
Patient in hospital
Predicate
PROCESS_OF
Object
Adult
12. Influenza PROCESS_OF Adult
Subject
Influenza
Predicate
PROCESS_OF
Object
Adult
13. Influenza PROCESS_OF Patients
Subject
Influenza
Predicate
PROCESS_OF
Object
Patients
14. COVID-19 CAUSES Influenza
Subject
COVID-19
Predicate
CAUSES
Object
Influenza
15. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
16. COVID-19 OCCURS_IN Patients
Subject
COVID-19
Predicate
OCCURS_IN
Object
Patients
17. Complication COEXISTS_WITH COVID-19
Subject
Complication
Predicate
COEXISTS_WITH
Object
COVID-19
18. Hospital admission TREATS Discharged Alive
Subject
Hospital admission
Predicate
TREATS
Object
Discharged Alive
ABSTRACT

BACKGROUND:

Novel coronavirus disease 2019 (COVID-19) is frequently compared with influenza. The Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN) conducts studies on the etiology and characteristics of U.S. hospitalized adults with influenza. It began enrolling patients with COVID-19 hospitalizations in March 2020. Patients with influenza were compared with those with COVID-19 in the first months of the U.S. epidemic.

METHODS:

Adults aged ≥ 18 years admitted to hospitals in 4 sites with acute respiratory illness were tested by real-time reverse transcription polymerase chain reaction for influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19. Demographic and illness characteristics were collected for influenza illnesses during 3 seasons 2016-2019. Similar data were collected on COVID-19 cases admitted before June 19, 2020.

RESULTS:

Age groups hospitalized with COVID-19 (n = 914) were similar to those admitted with influenza (n = 1937); 80% of patients with influenza and 75% of patients with COVID-19 were aged ≥50 years. Deaths from COVID-19 that occurred in younger patients were less often related to underlying conditions. White non-Hispanic persons were overrepresented in influenza (64%) compared with COVID-19 hospitalizations (37%). Greater severity and complications occurred with COVID-19 including more ICU admissions (AOR = 15.3 [95% CI 11.6, 20.3]), ventilator use (AOR = 15.6 [95% CI 10.7, 22.8]), 7 additional days of hospital stay in those discharged alive, and death during hospitalization (AOR = 19.8 [95% CI 12.0, 32.7]).

CONCLUSIONS:

While COVID-19 can cause a respiratory illness like influenza, it is associated with significantly greater severity of illness, longer hospital stays, and higher in-hospital deaths.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / COVID-19 Type of study: Etiology study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / COVID-19 Type of study: Etiology study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid