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S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated With Significantly Higher Viral Load in Samples Tested by TaqPath Polymerase Chain Reaction.
Kidd, Michael; Richter, Alex; Best, Angus; Cumley, Nicola; Mirza, Jeremy; Percival, Benita; Mayhew, Megan; Megram, Oliver; Ashford, Fiona; White, Thomas; Moles-Garcia, Emma; Crawford, Liam; Bosworth, Andrew; Atabani, Sowsan F; Plant, Tim; McNally, Alan.
  • Kidd M; Public Health England, Birmingham, United Kingdom.
  • Richter A; University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
  • Best A; Institute of Cancer and Genomic Science, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • Cumley N; Clinical Immunology Service, Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • Mirza J; Clinical Immunology Service, Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • Percival B; Clinical Immunology Service, Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • Mayhew M; Clinical Immunology Service, Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • Megram O; Clinical Immunology Service, Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • Ashford F; Clinical Immunology Service, Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • White T; Clinical Immunology Service, Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • Moles-Garcia E; Clinical Immunology Service, Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • Crawford L; Clinical Immunology Service, Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • Bosworth A; Clinical Immunology Service, Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom.
  • Atabani SF; University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
  • Plant T; Public Health England, Birmingham, United Kingdom.
  • McNally A; University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
J Infect Dis ; 223(10): 1666-1670, 2021 05 28.
Article in English | MEDLINE | ID: covidwho-1246717
ABSTRACT
A SARS-CoV-2 variant B1.1.7 containing mutation Δ69/70 has spread rapidly in the United Kingdom and shows an identifiable profile in ThermoFisher TaqPath RT-qPCR, S gene target failure (SGTF). We analyzed recent test data for trends and significance. Linked cycle threshold (Ct) values for respiratory samples showed that a low Ct for ORF1ab and N were clearly associated with SGTF. Significantly more SGTF samples had higher inferred viral loads between 1×107 and 1×108. Our conclusion is that patients whose samples exhibit the SGTF profile are more likely to have high viral loads, which may explain higher infectivity and rapidity of spread.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polymerase Chain Reaction / Viral Load / SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Variants Limits: Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polymerase Chain Reaction / Viral Load / SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Variants Limits: Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis