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The Impact of the COVID-19 Pandemic on Self-Reported Outcomes in Patients With Adrenal Insufficiency.
Li, Dingfeng; Suresh, Malavika; Abbondanza, Tiffany; Vaidya, Anand; Bancos, Irina.
  • Li D; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.
  • Suresh M; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.
  • Abbondanza T; Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
  • Vaidya A; Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
  • Bancos I; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.
J Clin Endocrinol Metab ; 106(7): e2469-e2479, 2021 06 16.
Article in English | MEDLINE | ID: covidwho-1247625
ABSTRACT
CONTEXT The COVID-19 pandemic has impacted healthcare environment.

OBJECTIVE:

To determine the impact of the pandemic on self-reported outcomes in patients with adrenal insufficiency (AI). DESIGN AND

SETTING:

Prospective longitudinal survey study at 2 tertiary centers.

PARTICIPANTS:

Patients with AI. INTERVENTION Patient-centered questionnaire. MAIN OUTCOME

MEASURES:

Depression Anxiety Stress Scales-21, Short Form-36, and AI self-management.

RESULTS:

Of 342 patients, 157 (46%) had primary AI, 109 (32%) had secondary AI, and 76 (22%) had glucocorticoid-induced AI. When compared to prepandemic, daily glucocorticoid dose and number of adrenal crises did not change. However, patients reported a higher financial impact from AI (34% vs 23%, P = 0.006) and difficulty accessing medical care (31% vs 7%, P < 0.0001) during the pandemic. A third of patients reported difficulty managing AI during the pandemic. After adjusting for duration and subtypes of AI, younger patients [odds ratio (OR) 2.3, CI 95% 1.3-4.1], women (OR 3.7, CI 95% 1.9-7.1), poor healthcare access(OR 4.2, CI 95% 2.3-7.7), lack of good insurance support (OR 2.8, CI 95% 1.3-5.9), and those with a higher financial impact (OR 2.3, CI 95% 1.3-4.3) reported greater difficulties managing AI. Patients were more likely to report a higher anxiety score (≥8) if they found managing AI challenging during the pandemic (OR 3.0, CI 95% 1.3-6.9), and had lower Physical Component Summary (OR 4.9, CI 95% 2.2-11.0) and Mental Component Summary (OR 4.1, CI 95% 1.8-9.5) scores prior to the pandemic.

CONCLUSIONS:

A third of patients with AI reported difficulties with management of AI during the pandemic, particularly in younger patients, women, and those with poor healthcare access.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Anxiety / Adrenal Insufficiency / Patient Reported Outcome Measures / Self-Management / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Qualitative research Country/Region as subject: North America Language: English Journal: J Clin Endocrinol Metab Year: 2021 Document Type: Article Affiliation country: Clinem

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Anxiety / Adrenal Insufficiency / Patient Reported Outcome Measures / Self-Management / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Qualitative research Country/Region as subject: North America Language: English Journal: J Clin Endocrinol Metab Year: 2021 Document Type: Article Affiliation country: Clinem