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Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2.
Parsons, Emily; Timlin, Matthew; Starr, Clarise; Fries, Anthony; Wells, Ronald; Studer, Matthew; Sainato, Rebecca.
  • Parsons E; Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA.
  • Timlin M; Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA.
  • Starr C; Applied Technology and Genomics Division, US Air Force School of Aerospace Medicine, Dayton, Ohio, USA.
  • Fries A; Applied Technology and Genomics Division, US Air Force School of Aerospace Medicine, Dayton, Ohio, USA.
  • Wells R; Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA.
  • Studer M; Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA.
  • Sainato R; Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA.
J Pediatric Infect Dis Soc ; 10(5): 695-697, 2021 May 28.
Article in English | MEDLINE | ID: covidwho-1249313
ABSTRACT
Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient's SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Viral / Systemic Inflammatory Response Syndrome / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Case report Topics: Variants Limits: Child / Humans / Male Language: English Journal: J Pediatric Infect Dis Soc Year: 2021 Document Type: Article Affiliation country: Jpids

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Viral / Systemic Inflammatory Response Syndrome / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Case report Topics: Variants Limits: Child / Humans / Male Language: English Journal: J Pediatric Infect Dis Soc Year: 2021 Document Type: Article Affiliation country: Jpids