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Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19.
May, Clive N; Bellomo, Rinaldo; Lankadeva, Yugeesh R.
  • May CN; Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
  • Bellomo R; Department of Critical Care, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia.
  • Lankadeva YR; Department of Critical Care, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia.
Br J Pharmacol ; 178(19): 3864-3868, 2021 10.
Article in English | MEDLINE | ID: covidwho-1402887
ABSTRACT
Sepsis induced by bacteria or viruses can result in multiorgan dysfunction, which is a major cause of death in intensive care units. Current treatments are only supportive, and there are no treatments that reverse the pathophysiological effects of sepsis. Vitamin C has antioxidant, anti-inflammatory, anticoagulant and immune modulatory actions, so it is a rational treatment for sepsis. Here, we summarise data that support the use of megadose vitamin C as a treatment for sepsis and COVID-19. Megadose intravenous sodium ascorbate (150 g per 40 kg over 7 h) dramatically improved the clinical state and cardiovascular, pulmonary, hepatic and renal function and decreased body temperature, in a clinically relevant ovine model of Gram-negative bacteria-induced sepsis. In a critically ill COVID-19 patient, intravenous sodium ascorbate (60 g) restored arterial pressure, improved renal function and increased arterial blood oxygen levels. These findings suggest that megadose vitamin C should be trialled as a treatment for sepsis and COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sepsis / COVID-19 Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Br J Pharmacol Year: 2021 Document Type: Article Affiliation country: Bph.15579

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sepsis / COVID-19 Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Br J Pharmacol Year: 2021 Document Type: Article Affiliation country: Bph.15579