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Nasopharyngeal Microbiota in SARS-CoV-2 Positive and Negative Patients.
Engen, Phillip A; Naqib, Ankur; Jennings, Cheryl; Green, Stefan J; Landay, Alan; Keshavarzian, Ali; Voigt, Robin M.
  • Engen PA; Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, 1725 W. Harrison St. STE 206, Chicago, IL, 60612, USA.
  • Naqib A; Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, 1725 W. Harrison St. STE 206, Chicago, IL, 60612, USA.
  • Jennings C; Department of Molecular Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA.
  • Green SJ; Genomics and Microbiome Core Facility, Rush University Medical Center, Chicago, IL, USA.
  • Landay A; Department of Internal Medicine, Division of Geriatrics and Palliative Medicine, Rush Medical College, Chicago, IL, USA.
  • Keshavarzian A; Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, 1725 W. Harrison St. STE 206, Chicago, IL, 60612, USA.
  • Voigt RM; Department of Physiology, Rush University Medical Center, Chicago, IL, USA.
Biol Proced Online ; 23(1): 10, 2021 Jun 01.
Article in English | MEDLINE | ID: covidwho-1249544
ABSTRACT
We investigated nasopharyngeal microbial community structure in COVID-19-positive and -negative patients. High-throughput 16S ribosomal RNA gene amplicon sequencing revealed significant microbial community structure differences between COVID-19-positive and -negative patients. This proof-of-concept study demonstrates that (1) nasopharyngeal microbiome communities can be assessed using collection samples already collected for SARS-CoV-2 testing (viral transport media) and (2) SARS-CoV-2 infection is associated with altered dysbiotic microbial profiles which could be a biomarker for disease progression and prognosis in SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Biol Proced Online Year: 2021 Document Type: Article Affiliation country: S12575-021-00148-6

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Biol Proced Online Year: 2021 Document Type: Article Affiliation country: S12575-021-00148-6