Immune responses to SARS-CoV-2

ABSTRACT

The clinical presentation of COVID-19 involves a broad range of symptoms and disease trajectories. Understanding the nature of the immune response that leads to recovery over severe disease is key to developing effective treatments for COVID-19. In this talk, I will discuss immune responses in COVID-19 patients with moderate and severe disease. I will compare viral load, immune phenotype, and cytokines that are predictive of mortality and discuss signatures of cytokines and growth factors that associate with recovery vs disease exacerbation. I will also discuss sex differences in immunity to SARS-CoV-2 and how such differences correspond to disease outcomes.