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Us population-based survey of vaccine willingness and sars-cov- 2 antibody prevalence
Topics in Antiviral Medicine ; 29(1):247, 2021.
Article in English | EMBASE | ID: covidwho-1250708
ABSTRACT

Background:

Developing representative estimates of COVID-19 vaccine acceptance will be essential to public health planning as the vaccine supply moves towards sufficiency in meeting initial levels of demand. We conducted a national probability household survey to assess vaccine willingness and history of SARS-CoV-2 infection based on antibody response.

Methods:

Study materials were sent to an address-based sample frame that includes nearly all residential addresses in the US. Participants completed a behavioral survey and dried blood spot (DBS) specimen collection for SARS-CoV-2 antibody testing during the study period, August 9 - December 8, 2020. Vaccine willingness was measured with a 5-point Likert scale item with responses ranging from “Very unlikely” to “Very likely.” Sample weights were calculated and applied to descriptive statistics and prevalence ratios (PR). We categorized persons as either Ig negative, Ig positive and aware of prior COVID-19 infection, or Ig positive and unaware of prior COVID-19 infection.

Results:

A total of 4,654 respondents completed the survey and had a valid antibody test result, representing 242,875,582 US adults. Overall, a substantial proportion, 32% (76,967,749 adults), were unsure or unwilling to receive a COVID-19 vaccine. Many groups at increased risk for SARS-CoV-2 had higher proportions unsure or unwilling, including Black (46%) relative to White (30%, p<.001) race, persons working outside home (38%) relative to at home (21%, p<.001), and smokers (44%) relative to nonsmokers (29%, p<.001) (Table 1). Dissonance between transmission risk and vaccine willingness was also observed in biologic data. Persons Ig positive (previously infected) and unaware of their status had a higher point estimate of unwillingness to be vaccinated (39%) than persons Ig negative with no history of infection (31%, p=.28). Overall, we estimate 12% (29,241,030 adults) were very unlikely to be vaccinated, 7% (15,729,748) were somewhat unlikely, 13% (31,996,971) were unsure, 19% (44,958,518) were likely, and 50% (119,820,865) were very likely.

Conclusion:

In the first national probability survey with biomarker data, we demonstrated that many groups with higher risk for COVID-19 infection had lower willingness to take a COVID-19 vaccine. This finding is in accordance with pre-existing fault-lines of inequity in our society. Substantial vaccine uptake promotion is needed, and should be targeted to address inequities correlated with vaccine willingness.
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Collection: Databases of international organizations Database: EMBASE Type of study: Observational study Topics: Vaccines Language: English Journal: Topics in Antiviral Medicine Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: EMBASE Type of study: Observational study Topics: Vaccines Language: English Journal: Topics in Antiviral Medicine Year: 2021 Document Type: Article