Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?
Diabetes Ther
; 12(4): 965-968, 2021 Apr.
Article
in English
| MEDLINE | ID: covidwho-1252261
ABSTRACT
Metformin remains the cornerstone of management for type 2 diabetes mellitus (T2DM). It is also known that it has beneficial pleiotropic actions. In addition, there is emerging evidence that this agent may prove beneficial in ameliorating depression in T2DM. The underlying mechanisms of this new action remain elusive, but experimental studies point to improved synaptic function and increased serotonin activity, along with the known inflammatory and antioxidant properties of metformin. Obviously, we need to further explore the potential utility of such antidepressant effects among T2DM subjects in everyday reality.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Diabetes Ther
Year:
2021
Document Type:
Article
Affiliation country:
S13300-021-01044-8
Similar
MEDLINE
...
LILACS
LIS