Identification of oligopeptides from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non structural protein 8 (NSP8) and their similarities with type 1 angiotensin II receptor key sites.
Biomed Pharmacother
; 141: 111722, 2021 Sep.
Article
in English
| MEDLINE | ID: covidwho-1252499
ABSTRACT
Coronavirus disease 2019 is associated with clinical symptoms including severe inflammatory syndrome and a higher expression of angiotensin II. As a pro-inflammatory mediator, the physiologic effects of angiotensin II are mediated by a G-protein coupled receptor, termed AT1R. Following binding, AT1R initiates the process of signal desensitization necessary to maintain cellular homeostasis. At the cellular level, this function occurs via the G protein-dependent signaling and the phosphorylation. We describe amino acids similarities between SARS COV-2 nonstructural protein (NSP8) which is associated with intracellular membranes and AT1R key sites. Since abnormal activation of AT1R receptor leads to a number of physiological disorders, we hypothesize that SARS COV-2 might further interfere with the angiotensin II receptor functions.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Oligopeptides
/
Viral Nonstructural Proteins
/
Receptor, Angiotensin, Type 1
/
Coronavirus RNA-Dependent RNA Polymerase
/
SARS-CoV-2
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Biomed Pharmacother
Year:
2021
Document Type:
Article
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