COVID-19 in 96 Patients With Hematologic Disease: The First Single-center Experience From the Czech Republic.
Clin Lymphoma Myeloma Leuk
; 21(9): 606-612, 2021 09.
Article
in English
| MEDLINE | ID: covidwho-1252599
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) represents an important infectious complication associated with high mortality rates in patients with hematologic diseases. There have not been published any epidemiologic studies from Czech Republic so far. PATIENTS ANDMETHODS:
This study is the first analysis of patients with hematologic malignancies and bone marrow failure syndromes treated at single hematology center in the Czech Republic between March 1 and December 31, 2020, in whom COVID-19 infection was confirmed.RESULTS:
The sample comprised 96 patients aged 26 to 84 years (median, 66.0 years). At the time of their COVID-19 diagnosis, 75 patients (78.1%) were treated for hematologic diseases. Twenty-seven patients (28.1%) in the sample had complete remission (CR) of their hematologic disease. They were nonsignificantly more likely to have asymptomatic to moderate COVID-19 infection than those who failed to achieve CR (74.1% vs. 56.5%; P = .06). A more severe course of the infection was significantly correlated with older age (P = .047). Lung involvement was also statistically significantly associated with older age (P = .045). Over the study period, a total of 15 patients died. Age greater than 60 years was significantly associated with deaths from COVID-19 (P = .036), with failure to achieve CR having a statistically nonsignificant impact on mortality (P = .22).CONCLUSION:
These results confirm the prognostic significance of age for achieving treatment response of hematologic disease as well as the severity and mortality of COVID-19 in hematology patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Hematologic Diseases
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Country/Region as subject:
Europa
Language:
English
Journal:
Clin Lymphoma Myeloma Leuk
Journal subject:
Neoplasms
Year:
2021
Document Type:
Article
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