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Variances in BCG protection against COVID-19 mortality: A global assessment.
Sarfraz, Zouina; Sarfraz, Azza; Pandav, Krunal; Singh Makkar, Sarabjot; Hasan Siddiqui, Saman; Patel, Gaurav; Platero-Portillo, Tania; Singh, Bishnu Mohan; Maideen, Mohamed Iburahim Haja; Sarvepalli, Deepika; Sarfraz, Muzna; Cardona-Guzman, Jose; Sanchez-Gonzalez, Marcos A; Cherrez-Ojeda, Ivan.
  • Sarfraz Z; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
  • Sarfraz A; Department of Research & Publication, Fatima Jinnah Medical University, Lahore, Pakistan.
  • Pandav K; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
  • Singh Makkar S; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Hasan Siddiqui S; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
  • Patel G; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
  • Platero-Portillo T; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Singh BM; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
  • Maideen MIH; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
  • Sarvepalli D; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
  • Sarfraz M; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
  • Cardona-Guzman J; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
  • Sanchez-Gonzalez MA; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
  • Cherrez-Ojeda I; Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
J Clin Tuberc Other Mycobact Dis ; 24: 100249, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1253158
ABSTRACT
The BCG vaccine is known to impart nonspecific immunological benefits alongside conferring protection to tuberculosis in endemic regions. It is also known to protect against bladder cancer and other respiratory tract infections. During the coronavirus disease 2019 (COVID-19) pandemic, the BCG vaccine has gained attention due to its role in conferring protective immunity. We demonstrate the potential immunological protective mechanisms that play a role against COVID-19. We conduct a global assessment of the countries that have the highest and lowest mortality rates determined by an a priori methodology. Lastly, we discuss the potential limitations of incorporating BCG vaccines as potential strategies against COVID-19 and provide recommendations regarding their use in ongoing and future epidemics.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: J Clin Tuberc Other Mycobact Dis Year: 2021 Document Type: Article Affiliation country: J.jctube.2021.100249

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: J Clin Tuberc Other Mycobact Dis Year: 2021 Document Type: Article Affiliation country: J.jctube.2021.100249