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Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions.
Thakur, Kiran T; Tamborska, Arina; Wood, Greta K; McNeill, Emily; Roh, David; Akpan, Imo J; Miller, Eliza C; Bautista, Alyssa; Claassen, Jan; Kim, Carla Y; Guekht, Alla; Pardo, Carlos A; Williams, Olajide; García-Azorín, David; Prasad, Kameshwar; Schmutzhard, Erich; Michael, Benedict D; Chou, Sherry H-Y; Winkler, Andrea S; Solomon, Tom; Elkind, Mitchell S.
  • Thakur KT; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA. Electronic address: ktt2115@cumc.columbia.edu.
  • Tamborska A; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK; Institute of Infection, Veterinary and Ecological Science, University of Liverpool, Liverpool, UK.
  • Wood GK; Institute of Infection, Veterinary and Ecological Science, University of Liverpool, Liverpool, UK.
  • McNeill E; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
  • Roh D; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
  • Akpan IJ; Department of Hematology/Oncology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
  • Miller EC; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
  • Bautista A; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
  • Claassen J; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
  • Kim CY; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
  • Guekht A; Moscow Research and Clinical Center for Neuropsychiatry & Russian National Research Medical University, Moscow, Russia.
  • Pardo CA; Divisions of Neuroimmunology and Neuroinfectious Disorders & Advanced Clinical Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Williams O; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
  • García-Azorín D; Headache Unit, Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
  • Prasad K; Rajendra Institute of Medical Sciences, Ranchi 834009, Jharkhand, India.
  • Schmutzhard E; Department of Neurology, Division of Neurocritical Care, Medical University Innsbruck, Innsbruck, Austria.
  • Michael BD; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital/Harvard University, Boston, MA, USA.
  • Chou SH; Department of Critical Care Medicine, Neurology, and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Winkler AS; Center for Global Health, Department of Neurology, Technical University of Munich, Munich, Germany; Centre for Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway.
  • Solomon T; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK.
  • Elkind MS; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
J Neurol Sci ; 427: 117532, 2021 08 15.
Article in English | MEDLINE | ID: covidwho-1253235
ABSTRACT

BACKGROUND:

Vaccine induced immune mediated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2·S Johnson and Johnson (Janssen/J&J). The evaluation and management of suspected cases of CVT post COVID-19 vaccination are critical skills for a broad range of healthcare providers.

METHODS:

A collaborative comprehensive review of literature was conducted among a global group of expert neurologists and hematologists.

FINDINGS:

Strategies for rapid evaluation and treatment of the CVT in the context of possible VITT exist, including inflammatory marker measurements, PF4 assays, and non-heparin anticoagulation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Venous Thrombosis / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: J Neurol Sci Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Venous Thrombosis / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: J Neurol Sci Year: 2021 Document Type: Article