[Role of the immune system in SARS-CoV-2 infection: immunopathology of COVID-19]. / Papel del sistema inmune en la infección por el SARS-CoV-2: inmunopatología de la COVID-19.
Medicine (Madr)
; 13(33): 1917-1931, 2021 May.
Article
in Spanish
| MEDLINE | ID: covidwho-1253370
ABSTRACT
The immune system is capable of adequately controlling SARS-CoV-2 infection in 81% of patients, whose disease is asymptomatic or who experience moderate symptoms. However, 19% of infected patients develop severe disease which can become critical or fatal. This review article intends to provide an overview of the epidemiological antecedents of ß-coronaviruses, describe the mechanisms of SARS-CoV-2 infection, and summarize the rational immunological underpinnings known at present which allow for a better understanding of the immunopathology of COVID-19. The SARS-CoV-2 virus is capable of profoundly altering the behavior of molecular and cellular components of the immune system. The initial decisions of the innate immune system are responsible for a proper or improper response of the adaptive immune system and, along with comorbidities, are directly associated with disease progression.
Full text:
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Collection:
International databases
Database:
MEDLINE
Language:
Spanish
Journal:
Medicine (Madr)
Year:
2021
Document Type:
Article
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