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Immune mediating molecules and pathogenesis of COVID-19-associated neurological disease.
Singh, HariOm; Singh, Amita; Khan, Abdul Arif; Gupta, Vivek.
  • Singh H; Department of Molecular Biology, ICMR-National AIDS Research Institute, Pune, India. Electronic address: hariomsgpgims@gmail.com.
  • Singh A; District Women Hospital, Prayagraj, UP, 211003, India.
  • Khan AA; Department of Microbiology, ICMR-National AIDS Research Institute, Pune, India.
  • Gupta V; Department of Biochemistry, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, 282001, India.
Microb Pathog ; 158: 105023, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1253397
ABSTRACT

BACKGROUND:

Long period of SARS-CoV-2 infection has been associated with psychiatric and cognitive disorders in adolescents and children. SARS-CoV-2 remains dormant in the CNS leading to neurological complications. The wide expression of ACE2 in the brain raises concern for its involvement in SARS-CoV-2 infection. Though, the mechanistic insights about blood-brain barriers (BBB) crossing by SARS-CoV-2 and further brain infection are still not clear. Moreover, the mechanism behind dormant SARS-CoV-2 infections leading to chronic neurological disorders needs to be unveiled. There is an urgent need to find out the risk factor involved in COVID-19-associated neurological disease. Therefore, the role of immune-associated genes in the pathogenesis of COVID-19 associated neurological diseases is presented which could contribute to finding associated genetic risk factors.

METHOD:

The search utilizing multiple databases, specifically, EMBASE, PubMed (Medline), and Google Scholar was performed. Moreover, the literature survey on the involvement of COVID-19, neuropathogenesis, and its consequences was done. DESCRIPTION Persistent inflammatory stimuli may promote the progression of neurodegenerative diseases. An increased expression level of cytokine, chemokine, and decreased expression level of immune cells has been associated with the COVID-19 patient. Cytokine storm was observed in severe COVID-19 patients. The nature of SARS-CoV-2 infection can be neuroinflammatory. Genes of immune response could be associated with neurodegenerative diseases.

CONCLUSION:

The present review will provide a useful framework and help in understanding COVID-19-associated neuropathogenesis. Experimental studies on immune-associated genes in COVID-19 patients with neurological manifestations could be helpful to establish its neuropathogenesis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neurodegenerative Diseases / COVID-19 Type of study: Observational study / Prognostic study / Reviews Limits: Adolescent / Humans Language: English Journal: Microb Pathog Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neurodegenerative Diseases / COVID-19 Type of study: Observational study / Prognostic study / Reviews Limits: Adolescent / Humans Language: English Journal: Microb Pathog Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article