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Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart.
Perrino, Cinzia; Ferdinandy, Péter; Bøtker, Hans E; Brundel, Bianca J J M; Collins, Peter; Davidson, Sean M; den Ruijter, Hester M; Engel, Felix B; Gerdts, Eva; Girao, Henrique; Gyöngyösi, Mariann; Hausenloy, Derek J; Lecour, Sandrine; Madonna, Rosalinda; Marber, Michael; Murphy, Elizabeth; Pesce, Maurizio; Regitz-Zagrosek, Vera; Sluijter, Joost P G; Steffens, Sabine; Gollmann-Tepeköylü, Can; Van Laake, Linda W; Van Linthout, Sophie; Schulz, Rainer; Ytrehus, Kirsti.
  • Perrino C; Department of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy.
  • Ferdinandy P; Department of Pharmacology and Pharmacotherapy, Semmelweis University, Nagyvárad tér 4, 1089 Budapest, Hungary.
  • Bøtker HE; Pharmahungary Group, Hajnoczy str. 6., H-6722 Szeged, Hungary.
  • Brundel BJJM; Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Blvd. 161, 8200 Aarhus, Denmark.
  • Collins P; Department of Physiology, Amsterdam UMC, Vrije Universiteit, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, Amsterdam, 1108 HV, the Netherlands.
  • Davidson SM; Imperial College, Faculty of Medicine, National Heart & Lung Institute, South Kensington Campus, London SW7 2AZ, UK.
  • den Ruijter HM; Royal Brompton Hospital, Sydney St, Chelsea, London SW3 6NP, UK.
  • Engel FB; The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX London, UK.
  • Gerdts E; Experimental Cardiology Laboratory, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
  • Girao H; Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Muscle Research Center Erlangen (MURCE), Schwabachanlage 12, 91054 Erlangen, Germany.
  • Gyöngyösi M; Department for Clinical Science, University of Bergen, PO Box 7804, 5020 Bergen, Norway.
  • Hausenloy DJ; Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Azinhaga Santa Comba, Celas, 3000-548 Coimbra, Portugal.
  • Lecour S; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, and Clinical Academic Centre of Coimbra (CACC), 3000-548 Coimbra, Portugal.
  • Madonna R; Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
  • Marber M; Cardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, 169857, Singapore.
  • Murphy E; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore.
  • Pesce M; Yong Loo Lin School of Medicine, National University Singapore, 1E Kent Ridge Road, 119228, Singapore.
  • Regitz-Zagrosek V; The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London WC1E 6HX, UK.
  • Sluijter JPG; Cardiovascular Research Center, College of Medical and Health Sciences, Asia University, 500, Lioufeng Rd., Wufeng, Taichung 41354, Taiwan.
  • Steffens S; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, Chris Barnard Building, University of Cape Town, Private Bag X3 7935 Observatory, Cape Town, South Africa.
  • Gollmann-Tepeköylü C; Institute of Cardiology, University of Pisa, Lungarno Antonio Pacinotti 43, 56126 Pisa, Italy.
  • Van Laake LW; Department of Internal Medicine, University of Texas Medical School in Houston, 6410 Fannin St #1014, Houston, TX 77030, USA.
  • Van Linthout S; King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK.
  • Schulz R; Laboratory of Cardiac Physiology, Cardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD 20892, USA.
  • Ytrehus K; Unità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS Via Parea, 4, I-20138 Milan, Italy.
Cardiovasc Res ; 117(2): 367-385, 2021 01 21.
Article in English | MEDLINE | ID: covidwho-1254643
ABSTRACT
Ischaemic heart disease (IHD) is a complex disorder and a leading cause of death and morbidity in both men and women. Sex, however, affects several aspects of IHD, including pathophysiology, incidence, clinical presentation, diagnosis as well as treatment and outcome. Several diseases or risk factors frequently associated with IHD can modify cellular signalling cascades, thus affecting ischaemia/reperfusion injury as well as responses to cardioprotective interventions. Importantly, the prevalence and impact of risk factors and several comorbidities differ between males and females, and their effects on IHD development and prognosis might differ according to sex. The cellular and molecular mechanisms underlying these differences are still poorly understood, and their identification might have important translational implications in the prediction or prevention of risk of IHD in men and women. Despite this, most experimental studies on IHD are still undertaken in animal models in the absence of risk factors and comorbidities, and assessment of potential sex-specific differences are largely missing. This ESC WG Position Paper will discuss (i) the importance of sex as a biological variable in cardiovascular research, (ii) major biological mechanisms underlying sex-related differences relevant to IHD risk factors and comorbidities, (iii) prospects and pitfalls of preclinical models to investigate these associations, and finally (iv) will provide recommendations to guide future research. Although gender differences also affect IHD risk in the clinical setting, they will not be discussed in detail here.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Myocardial Ischemia / Health Status Disparities / Translational Research, Biomedical Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Animals / Female / Humans / Male Language: English Journal: Cardiovasc Res Year: 2021 Document Type: Article Affiliation country: Cvr

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Myocardial Ischemia / Health Status Disparities / Translational Research, Biomedical Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Animals / Female / Humans / Male Language: English Journal: Cardiovasc Res Year: 2021 Document Type: Article Affiliation country: Cvr