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Promising effects of atorvastatin on mortality and need for mechanical ventilation in patients with severe COVID-19; a retrospective cohort study.
Haji Aghajani, Mohammad; Moradi, Omid; Azhdari Tehrani, Hamed; Amini, Hossein; Pourheidar, Elham; Hatami, Firouze; Rabiei, Mohammad Mahdi; Sistanizad, Mohammad.
  • Haji Aghajani M; Prevention of Cardiovascular Disease Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Moradi O; Department of Clinical Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Azhdari Tehrani H; Department of Hematology and Medical Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Amini H; Department of Clinical Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Pourheidar E; Department of Clinical Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Hatami F; Clinical Research Development Unit of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Rabiei MM; Clinical Research Development Unit of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Sistanizad M; Prevention of Cardiovascular Disease Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Clin Pract ; 75(9): e14434, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1255410
Semantic information from SemMedBD (by NLM)
1. Mechanical ventilation TREATS COVID-19
Subject
Mechanical ventilation
Predicate
TREATS
Object
COVID-19
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Mechanical ventilation TREATS Patients
Subject
Mechanical ventilation
Predicate
TREATS
Object
Patients
4. COVID-19 CAUSES Coronary Arteriosclerosis
Subject
COVID-19
Predicate
CAUSES
Object
Coronary Arteriosclerosis
5. COVID-19 CAUSES Hypertensive disease
Subject
COVID-19
Predicate
CAUSES
Object
Hypertensive disease
6. atorvastatin ADMINISTERED_TO Patients
Subject
atorvastatin
Predicate
ADMINISTERED_TO
Object
Patients
7. Coronary Arteriosclerosis PROCESS_OF Patients
Subject
Coronary Arteriosclerosis
Predicate
PROCESS_OF
Object
Patients
8. Hypertensive disease PROCESS_OF Patients
Subject
Hypertensive disease
Predicate
PROCESS_OF
Object
Patients
9. Mechanical ventilation TREATS COVID-19
Subject
Mechanical ventilation
Predicate
TREATS
Object
COVID-19
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Mechanical ventilation TREATS Patients
Subject
Mechanical ventilation
Predicate
TREATS
Object
Patients
12. COVID-19 CAUSES Coronary Arteriosclerosis
Subject
COVID-19
Predicate
CAUSES
Object
Coronary Arteriosclerosis
13. COVID-19 CAUSES Hypertensive disease
Subject
COVID-19
Predicate
CAUSES
Object
Hypertensive disease
14. atorvastatin ADMINISTERED_TO Patients
Subject
atorvastatin
Predicate
ADMINISTERED_TO
Object
Patients
15. Coronary Arteriosclerosis PROCESS_OF Patients
Subject
Coronary Arteriosclerosis
Predicate
PROCESS_OF
Object
Patients
16. Hypertensive disease PROCESS_OF Patients
Subject
Hypertensive disease
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

PURPOSE:

Considering the anti-inflammatory effect of atorvastatin and the role of medical comorbidities such as hypertension and coronary artery disease on the prognosis of the COVID-19 patients, we aimed to assess the effect of atorvastatin add-on therapy on mortality caused by COVID-19.

METHODS:

We conducted a retrospective cohort study, including patients who were hospitalised with confirmed diagnosis of severe COVID-19. Baseline characteristics and related clinical data of patients were recorded. Clinical outcomes consist of in-hospital mortality, need for invasive mechanical ventilation and hospital length of stay. COX regression analysis models were used to assess the association of independent factors to outcomes.

RESULTS:

Atorvastatin was administered for 421 of 991 patients. The mean age was 61.640 ± 17.003 years. Older age, higher prevalence of hypertension and coronary artery disease reported in patients who received atorvastatin. These patients have shorter hospital length of stay (P = .001). Based on COX proportional hazard model, in-hospital use of atorvastatin was associated with decrease in mortality (HR = 0.679, P = .005) and lower need for invasive mechanical ventilation (HR = 0.602, P = .014).

CONCLUSIONS:

Atorvastatin add-on therapy in patient with severe COVID-19 was associated with lower in-hospital mortality and reduced the risk of need for invasive mechanical ventilation which supports to continue the prescription of the medication.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Humans / Middle aged Language: English Journal: Int J Clin Pract Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Ijcp.14434

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Humans / Middle aged Language: English Journal: Int J Clin Pract Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Ijcp.14434