Your browser doesn't support javascript.
Obesity-Related Inflammation and Endothelial Dysfunction in COVID-19: Impact on Disease Severity.
De Lorenzo, Andrea; Estato, Vanessa; Castro-Faria-Neto, Hugo C; Tibirica, Eduardo.
  • De Lorenzo A; Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brazil.
  • Estato V; Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brail.
  • Castro-Faria-Neto HC; Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brail.
  • Tibirica E; Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brazil.
J Inflamm Res ; 14: 2267-2276, 2021.
Article in English | MEDLINE | ID: covidwho-1256169
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic has put into evidence another pandemic - obesity. Currently, several studies have documented the association between obesity and COVID-19 severity. The mechanisms underlying the increased risk of complications and mortality in obese patients with COVID-19 are of diverse nature. Inflammation plays a central role in obesity. Metabolic alterations seen in obese patients are related to an inflammatory response, and several studies report elevated levels of circulating inflammatory cytokines in obese patients. Also, deregulated expression of adipokines, such as leptin and resistin, increase the expression of vascular adhesion molecule 1 and intercellular adhesion molecule 1 that contribute to increased vascular leukocyte adhesiveness and additional oxidative stress. Additionally, it is now recognized that the chronic impairment of systemic vascular endothelial function in patients with cardiovascular and metabolic disorders, including obesity, when intensified by the detrimental effects of SARS-CoV-2 over the endothelium, may explain their worse outcomes in COVID-19. In fact, vascular endothelial dysfunction may contribute to a unfavorable response of the endothelium to the infection by SARS-CoV-2, whereas alterations in cardiac structure and function and the prothrombotic environment in obesity may also provide a link to the increased cardiovascular events in these patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: J Inflamm Res Year: 2021 Document Type: Article Affiliation country: JIR.S282710

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: J Inflamm Res Year: 2021 Document Type: Article Affiliation country: JIR.S282710