Evaluation of Dual Inhibitory Effect of Anagliptin, Ramipril and Lisinopril on Angiotensin-Converting Enzyme and DPP-4 Activities.
Curr Mol Pharmacol
; 15(3): 582-588, 2022.
Article
in English
| MEDLINE | ID: covidwho-1256219
ABSTRACT
BACKGROUND:
We previously tested two angiotensin-converting enzyme (ACE) inhibitors and two dipeptidyl peptidase-4 (DPP-4) inhibitors for dual enzyme inhibitory effect. Only two DPP-4 inhibitors, linagliptin and sitagliptin, were able to inhibit ACE.OBJECTIVE:
In the present study, we investigated if other inhibitors of ACE or DPP-4 could simultaneously inhibit the activities of both DPP-4 and ACE.METHODS:
Forty Sprague Dawley rats were used. The control group received only saline. The other three groups were treated with anagliptin, ramipril, or lisinopril. Two different doses were tested separated with a 6-day drug-free interval. Angiotensin II (Ang II) levels and the activities of ACE and DPP-4 were measured from blood samples at baseline and days 1, 10, and 14. After the oral glucose challenge test, levels of the active form of glucagon-like peptide-1 (GLP-1) were measured.RESULTS:
Regardless of the dose, anagliptin did not show any inhibitory effect on the activity of ACE or Ang II levels. Concerning ramipril and lisinopril, only a high dose of lisinopril was able to produce a modest reduction of the DPP-4 activity but not enough to inhibit the inactivation of GLP-1.CONCLUSION:
It seems that while most of the ACE inhibitors cannot affect DPP-4 activity, inhibitors of DPP-4 vary in their effects on ACE activity. The selection of DPP-4 inhibitors under different clinical situations should take into account the action of these drugs on ACE.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Lisinopril
/
Dipeptidyl-Peptidase IV Inhibitors
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
Limits:
Animals
Language:
English
Journal:
Curr Mol Pharmacol
Journal subject:
Pharmacology
Year:
2022
Document Type:
Article
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