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Epidemiological and clinical characteristics of early COVID-19 cases, United Kingdom of Great Britain and Northern Ireland.
Boddington, Nicola L; Charlett, Andre; Elgohari, Suzanne; Byers, Chloe; Coughlan, Laura; Vilaplana, Tatiana Garcia; Whillock, Rosie; Sinnathamby, Mary; Panagiotopoulos, Nikolaos; Letley, Louise; MacDonald, Pauline; Vivancos, Roberto; Edeghere, Obaghe; Shingleton, Joseph; Bennett, Emma; Cottrell, Simon; McMenamin, Jim; Zambon, Maria; Ramsay, Mary; Dabrera, Gavin; Saliba, Vanessa; Bernal, Jamie Lopez.
  • Boddington NL; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Charlett A; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Elgohari S; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Byers C; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Coughlan L; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Vilaplana TG; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Whillock R; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Sinnathamby M; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Panagiotopoulos N; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Letley L; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • MacDonald P; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Vivancos R; Public Health England, Liverpool, England.
  • Edeghere O; Public Health England, Liverpool, England.
  • Shingleton J; Public Health England, Salisbury, England.
  • Bennett E; Public Health England, Salisbury, England.
  • Cottrell S; Public Health Wales, Cardiff, Wales.
  • McMenamin J; Health Protection Scotland, Glasgow, Scotland.
  • Zambon M; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Ramsay M; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Dabrera G; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Saliba V; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
  • Bernal JL; Public Health England, 61 Colindale Avenue, London, NW9 5EQ, England.
Bull World Health Organ ; 99(3): 178-189, 2021 Mar 01.
Article in English | MEDLINE | ID: covidwho-1256313
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
2. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
ABSTRACT

OBJECTIVE:

To describe the clinical presentation, course of disease and health-care seeking behaviour of the first few hundred cases of coronavirus disease 2019 (COVID-19) in the United Kingdom of Great Britain and Northern Ireland.

METHODS:

We implemented the World Health Organization's First Few X cases and contacts investigation protocol for COVID-19. Trained public health professionals collected information on 381 virologically confirmed COVID-19 cases from 31 January 2020 to 9 April 2020. We actively followed up cases to identify exposure to infection, symptoms and outcomes. We also collected limited data on 752 symptomatic people testing negative for COVID-19, as a control group for analyses of the sensitivity, specificity and predictive value of symptoms.

FINDINGS:

Approximately half of the COVID-19 cases were imported (196 cases; 51.4%), of whom the majority had recent travel to Italy (140 cases; 71.4%). Of the 94 (24.7%) secondary cases, almost all reported close contact with a confirmed case (93 cases; 98.9%), many through household contact (37 cases; 39.8%). By age, a lower proportion of children had COVID-19. Most cases presented with cough, fever and fatigue. The sensitivity and specificity of symptoms varied by age, with nonlinear relationships with age. Although the proportion of COVID-19 cases with fever increased with age, for those with other respiratory infections the occurrence of fever decreased with age. The occurrence of shortness of breath also increased with age in a greater proportion of COVID-19 cases.

CONCLUSION:

The study has provided useful evidence for generating case definitions and has informed modelling studies of the likely burden of COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Clinical Practice Guide / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Bull World Health Organ Year: 2021 Document Type: Article Affiliation country: Blt.20.265603

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Clinical Practice Guide / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Bull World Health Organ Year: 2021 Document Type: Article Affiliation country: Blt.20.265603