The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System.
Front Immunol
; 11: 580304, 2020.
Article
in English
| MEDLINE | ID: covidwho-1256375
ABSTRACT
Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses. Given the capability to connect crux inflammations of adaptive and innate immunity, γδ T cells are responsive to multiple molecular cues and can acquire the capacity to induce various cytokines, such as GM-CSF, IL-4, IL-17, IL-21, IL-22, and IFN-γ. Nevertheless, the exact mechanisms responsible for γδ T cell proinflammatory functions remain poorly understood, particularly in the context of the central nervous system (CNS) diseases. CNS disease, usually leading to irreversible cognitive and physical disability, is becoming a worldwide public health problem. Here, we offer a review of the neuro-inflammatory and immune functions of γδ T cells, intending to understand their roles in CNS diseases, which may be crucial for the development of novel clinical applications.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Central Nervous System Diseases
/
Th17 Cells
/
Intraepithelial Lymphocytes
/
Inflammation
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Front Immunol
Year:
2020
Document Type:
Article
Affiliation country:
Fimmu.2020.580304
Similar
MEDLINE
...
LILACS
LIS