State of the art on lung organoids in mammals.
Vet Res
; 52(1): 77, 2021 Jun 02.
Article
in English
| MEDLINE | ID: covidwho-1257965
ABSTRACT
The number and severity of diseases affecting lung development and adult respiratory function have stimulated great interest in developing new in vitro models to study lung in different species. Recent breakthroughs in 3-dimensional (3D) organoid cultures have led to new physiological in vitro models that better mimic the lung than conventional 2D cultures. Lung organoids simulate multiple aspects of the real organ, making them promising and useful models for studying organ development, function and disease (infection, cancer, genetic disease). Due to their dynamics in culture, they can serve as a sustainable source of functional cells (biobanking) and be manipulated genetically. Given the differences between species regarding developmental kinetics, the maturation of the lung at birth, the distribution of the different cell populations along the respiratory tract and species barriers for infectious diseases, there is a need for species-specific lung models capable of mimicking mammal lungs as they are of great interest for animal health and production, following the One Health approach. This paper reviews the latest developments in the growing field of lung organoids.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Organoids
/
Tissue Culture Techniques
/
Lung
/
Mammals
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Vet Res
Journal subject:
Veterinary Medicine
Year:
2021
Document Type:
Article
Affiliation country:
S13567-021-00946-6
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