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A review of nasopharyngeal swab and saliva tests for SARS-CoV-2 infection: Disease timelines, relative sensitivities, and test optimization.
Roque, Marylin; Proudfoot, Kevin; Mathys, Vadim; Yu, Sophie; Krieger, Natalie; Gernon, Thomas; Gokli, Kash; Hamilton, Stanley; Cook, Colin; Fong, Yuman.
  • Roque M; Department of Engineering, Harvey Mudd College, Claremont, California, USA.
  • Proudfoot K; Department of Engineering, Harvey Mudd College, Claremont, California, USA.
  • Mathys V; Department of Engineering, Harvey Mudd College, Claremont, California, USA.
  • Yu S; Department of Engineering, Harvey Mudd College, Claremont, California, USA.
  • Krieger N; Department of Engineering, Harvey Mudd College, Claremont, California, USA.
  • Gernon T; Department of Surgery, City of Hope Medical Center, Duarte, California, USA.
  • Gokli K; Department of Engineering, Harvey Mudd College, Claremont, California, USA.
  • Hamilton S; Department of Pathology, City of Hope Medical Center, Duarte, California, USA.
  • Cook C; Department of Surgery, City of Hope Medical Center, Duarte, California, USA.
  • Fong Y; Department of Surgery, City of Hope Medical Center, Duarte, California, USA.
J Surg Oncol ; 124(4): 465-475, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1258085
ABSTRACT
Testing is an essential part of containment of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. This review summarizes studies for SARS-CoV-2 infection and testing. Nasopharyngeal samples are best at sensitivity detection, especially in early stages of disease and in asymptomatic individuals. Current swab processing involves a 100- to 1000-fold dilution of the patient sample. Future optimization of testing should focus on using smaller volumes of viral transport media and swab designs to increase comfort and increased viral adhesion.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Sputum / Nasopharynx / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Humans Language: English Journal: J Surg Oncol Year: 2021 Document Type: Article Affiliation country: Jso.26561

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Sputum / Nasopharynx / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Humans Language: English Journal: J Surg Oncol Year: 2021 Document Type: Article Affiliation country: Jso.26561