COVID-19 pneumonia in a patient with granulomatosis with polyangiitis on rituximab: case-based review.
Rheumatol Int
; 41(8): 1509-1514, 2021 08.
Article
in English
| MEDLINE | ID: covidwho-1258195
ABSTRACT
A 77-year-old man with past medical history of granulomatosis with polyangiitis (GPA) on rituximab and prednisone, presented to the hospital with worsening cough and shortness of breath. He had tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by nasal swab polymerase chain reaction (PCR) while asymptomatic, 6 weeks earlier. He started with cough and shortness of breath 2 weeks after his initial positive test. After developing symptoms, he tested negative twice by nasal swab PCR, but the PCR of his bronchioloalveolar lavage was positive for SARS-CoV-2. He did not develop antibodies against coronavirus. Prednisone 15 mg daily was continued, and he received remdesivir, and convalescent plasma with quick recovery. We reviewed the literature to search for similar cases. Our case suggests that SARS-CoV-2 infection in patients on rituximab may have an atypical presentation and the diagnosis may be delayed due to negative PCR testing in the nasal swab. Patients may benefit from treatment with convalescent plasma.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Granulomatosis with Polyangiitis
/
Rituximab
/
SARS-CoV-2
/
COVID-19
/
Immunosuppressive Agents
Type of study:
Case report
/
Diagnostic study
/
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Rheumatol Int
Year:
2021
Document Type:
Article
Affiliation country:
S00296-021-04905-4
Similar
MEDLINE
...
LILACS
LIS