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Chronic liver disease not a significant comorbid condition for COVID-19.
Lin, Jiahao; Bao, Bingting; Khurram, Nigar Anjuman; Halsey, Kasey; Choi, Ji Whae; Wang, Lesan; Tran, Thi My Linh; Liao, Wei-Hua; Feldman, Michael D; Zhang, Paul J; Wu, Jing; Bai, Harrison X.
  • Lin J; Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Bao B; Xiangya Medical School, Central South University, Changsha, 410013, Hunan, China.
  • Khurram NA; Department of Pathology, University of California, San Francisco, 91413, USA.
  • Halsey K; Department of Diagnostic Imaging, Rhode Island Hospital, Philadelphia, PA, 19104, USA.
  • Choi JW; Warren Alpert Medical School, Brown University, Rhode Island Hospital, Providence, RI, 02903, USA.
  • Wang L; Department of Diagnostic Imaging, Rhode Island Hospital, Philadelphia, PA, 19104, USA.
  • Tran TML; Warren Alpert Medical School, Brown University, Rhode Island Hospital, Providence, RI, 02903, USA.
  • Liao WH; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, 410008, Hunan, China.
  • Feldman MD; Department of Diagnostic Imaging, Rhode Island Hospital, Philadelphia, PA, 19104, USA.
  • Zhang PJ; Warren Alpert Medical School, Brown University, Rhode Island Hospital, Providence, RI, 02903, USA.
  • Wu J; Department of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
  • Bai HX; Department of Pathology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Sci Rep ; 11(1): 11734, 2021 06 03.
Article in English | MEDLINE | ID: covidwho-1258596
Semantic information from SemMedBD (by NLM)
1. Chronic liver disease AFFECTS COVID-19
Subject
Chronic liver disease
Predicate
AFFECTS
Object
COVID-19
2. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. Liver LOCATION_OF Autopsy
Subject
Liver
Predicate
LOCATION_OF
Object
Autopsy
5. Chronic liver disease PROCESS_OF Patients
Subject
Chronic liver disease
Predicate
PROCESS_OF
Object
Patients
6. Chronic liver disease AFFECTS COVID-19
Subject
Chronic liver disease
Predicate
AFFECTS
Object
COVID-19
7. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
8. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
9. Liver LOCATION_OF Autopsy
Subject
Liver
Predicate
LOCATION_OF
Object
Autopsy
10. Chronic liver disease PROCESS_OF Patients
Subject
Chronic liver disease
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
To explore the role of chronic liver disease (CLD) in COVID-19. A total of 1439 consecutively hospitalized patients with COVID-19 from one large medical center in the United States from March 16, 2020 to April 23, 2020 were retrospectively identified. Clinical characteristics and outcomes were compared between patients with and without CLD. Postmortem examination of liver in 8 critically ill COVID-19 patients was performed. There was no significant difference in the incidence of CLD between critical and non-critical groups (4.1% vs 2.9%, p = 0.259), or COVID-19 related liver injury between patients with and without CLD (65.7% vs 49.7%, p = 0.065). Postmortem examination of liver demonstrated mild liver injury associated central vein outflow obstruction and minimal to moderate portal lymphocytic infiltrate without evidence of CLD. Patients with CLD were not associated with a higher risk of liver injury or critical/fatal outcomes. CLD was not a significant comorbid condition for COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Diseases Type of study: Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-91238-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Diseases Type of study: Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-91238-8