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Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution.
Colombo, Federico; Corsiero, Elisa; Lewis, Myles J; Pitzalis, Costantino.
  • Colombo F; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK. f.colombo@qmul.ac.uk.
  • Corsiero E; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK. e.corsiero@qmul.ac.uk.
  • Lewis MJ; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
  • Pitzalis C; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
Sci Rep ; 11(1): 11773, 2021 06 03.
Article in English | MEDLINE | ID: covidwho-1258597
ABSTRACT
Since the first report of SARS-CoV-2 in China in 2019, there has been a huge debate about the origin. In this work, using a different method we aimed to strengthen the observation that no evidence of genetic manipulation has been found by (1) detecting classical restriction site (RS) sequence in human SARS-CoV-2 genomes and (2) comparing them with other recombinant SARS-CoV-like virus created for experimental purposes. Finally, we propose a novel approach consisting in the generation of a restriction endonucleases site map of SARS-CoV-2 and other related coronavirus genomes to be used as a fingerprint to trace the virus evolution.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: DNA Restriction Enzymes / Biological Evolution / DNA Barcoding, Taxonomic / SARS-CoV-2 Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-91264-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: DNA Restriction Enzymes / Biological Evolution / DNA Barcoding, Taxonomic / SARS-CoV-2 Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-91264-6