Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution.
Sci Rep
; 11(1): 11773, 2021 06 03.
Article
in English
| MEDLINE | ID: covidwho-1258597
ABSTRACT
Since the first report of SARS-CoV-2 in China in 2019, there has been a huge debate about the origin. In this work, using a different method we aimed to strengthen the observation that no evidence of genetic manipulation has been found by (1) detecting classical restriction site (RS) sequence in human SARS-CoV-2 genomes and (2) comparing them with other recombinant SARS-CoV-like virus created for experimental purposes. Finally, we propose a novel approach consisting in the generation of a restriction endonucleases site map of SARS-CoV-2 and other related coronavirus genomes to be used as a fingerprint to trace the virus evolution.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
DNA Restriction Enzymes
/
Biological Evolution
/
DNA Barcoding, Taxonomic
/
SARS-CoV-2
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Sci Rep
Year:
2021
Document Type:
Article
Affiliation country:
S41598-021-91264-6
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