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COVID-19 and HIV/AIDS in a cohort study in Sao Paulo, Brazil: outcomes and disparities by race and schooling.
Rocha, S Q; Avelino-Silva, V I; Tancredi, M V; Jamal, L F; Ferreira, P R A; Tayra, A; Ferreira, P M; Carvalhanas, T; Domingues, C S B; Souza, R A; Gianna, M C; Kalichman, A O; Leite, O H M; Souza, T N L; Gomes E Costa, D A; Furtado, J J D; Costa, A F.
  • Rocha SQ; Centro de Referência e Treinamento DST/Aids - São Paulo (CRT-DST/Aids) Sao Paulo, Brazil.
  • Avelino-Silva VI; Department of Infectious and Parasitic Diseases, Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, Brazil.
  • Tancredi MV; Centro de Referência e Treinamento DST/Aids - São Paulo (CRT-DST/Aids) Sao Paulo, Brazil.
  • Jamal LF; Centro de Referência e Treinamento DST/Aids - São Paulo (CRT-DST/Aids) Sao Paulo, Brazil.
  • Ferreira PRA; Disciplina de Infectologia, Escola Paulista de Medicina - Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
  • Tayra A; Centro de Referência e Treinamento DST/Aids - São Paulo (CRT-DST/Aids) Sao Paulo, Brazil.
  • Ferreira PM; Centro de Vigilância Epidemiológica - São Paulo (CVE), São Paulo, Brazil.
  • Carvalhanas T; Centro de Vigilância Epidemiológica - São Paulo (CVE), São Paulo, Brazil.
  • Domingues CSB; Centro de Referência e Treinamento DST/Aids - São Paulo (CRT-DST/Aids) Sao Paulo, Brazil.
  • Souza RA; Centro de Referência e Treinamento DST/Aids - São Paulo (CRT-DST/Aids) Sao Paulo, Brazil.
  • Gianna MC; Centro de Referência e Treinamento DST/Aids - São Paulo (CRT-DST/Aids) Sao Paulo, Brazil.
  • Kalichman AO; Centro de Referência e Treinamento DST/Aids - São Paulo (CRT-DST/Aids) Sao Paulo, Brazil.
  • Leite OHM; Faculdade de Medicina do ABC - Centro Universitário Saúde do ABC (FM-ABC) Santo Andre, Brazil.
  • Souza TNL; Instituto de Infectologia Emílio Ribas - SES/SP (IIER), São Paulo, Brazil.
  • Gomes E Costa DA; Hospital do Servidor Público Estadual de São Paulo (HSPE), São Paulo, Brazil.
  • Furtado JJD; Hospital Heliópolis, Sao Paulo, Brazil.
  • Costa AF; Centro de Referência e Treinamento DST/Aids - São Paulo (CRT-DST/Aids) Sao Paulo, Brazil.
AIDS Care ; : 1-7, 2021 Jun 04.
Article in English | MEDLINE | ID: covidwho-1258667
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Persons
Subject
COVID-19
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PROCESS_OF
Object
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2. Cessation of life PROCESS_OF Persons
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Cessation of life
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3. race: mixed PROCESS_OF Patients
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4. COVID-19 PROCESS_OF Persons
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5. Cessation of life PROCESS_OF Persons
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Cessation of life
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PROCESS_OF
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6. race: mixed PROCESS_OF Patients
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race: mixed
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ABSTRACT
Studies describing characteristics and outcomes of COVID-19 among people living with HIV are currently limited, lacking detailed evaluation of the interplay among demographics, HIV-related variables, and comorbidities on COVID-19 outcomes. This retrospective cohort study describes mortality rates overall and according to demographic characteristics and explores predictors of admission to intensive care unit and death among 255 persons living with HIV with severe acute respiratory syndrome and confirmed SARS-CoV-2 infection in the State of Sao Paulo, Brazil. We found that the overall mortality rate was 4.1/1,000 person-days, with a case-fatality of 34%. Higher rates occurred among older adults, Black/Mixed skin color/race patients, and those with lower schooling. In a multivariable analysis adjusted for age, sex, CD4 count, viral load and number of comorbidities, skin color/race, and schooling remained significantly associated with higher mortality. Although tenofovir use was more frequent among survivors in the univariable analysis, we failed to find a statistically significant association between tenofovir use and survival in the multivariable analysis. Our findings suggest that social vulnerabilities related to both HIV and COVID-19 significantly impact the risk of death, overtaking traditional risk factors such as age, sex, CD4 count, and comorbidities.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Prognostic study / Risk factors Country/Region as subject: South America / Brazil Language: English Journal: AIDS Care Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2021 Document Type: Article Affiliation country: 09540121.2021.1936444

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Prognostic study / Risk factors Country/Region as subject: South America / Brazil Language: English Journal: AIDS Care Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2021 Document Type: Article Affiliation country: 09540121.2021.1936444