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Reported adverse effects following COVID-19 vaccination at a tertiary care hospital, focus on cerebral venous sinus thrombosis (CVST).
Esba, Laila Carolina Abu; Al Jeraisy, Majed.
  • Esba LCA; Pharmaceutical Care Services, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia.
  • Al Jeraisy M; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Expert Rev Vaccines ; 20(8): 1037-1042, 2021 08.
Article in English | MEDLINE | ID: covidwho-1258700
ABSTRACT

Objectives:

Several cases of unusual thrombotic events with thrombocytopenia were reported in several countries, in association with AstraZeneca's COVID-19 vaccine. The European medicines agency conducted a detailed review and concluded that there was no evidence to suggest an association of thrombotic events with the use of COVID-19 vaccine AstraZeneca.

Methods:

King Abdulaziz Medical City is a 1500 bed tertiary care hospital in Riyadh, Saudi Arabia; this study describes spontaneously reported vaccine adverse effects received through the hospital's internal electronic safety reporting system from December 2020 to 13 April 2021.We assessed each report for causality association utilizing the world health organization's (WHO) causality assessment of an adverse event following immunization (AEFI) classification 2nd Edition 2019.

Results:

The majority of the reported events were mild to moderate, there were five serious events, one reported cardiac arrest, two cerebral venous sinus thrombosis, and two pulmonary embolism. Clinical and laboratory summary of the five patients are presented in detail.

Conclusions:

Efforts of pharmacovigilance in mediating the rare risk of thrombosis associated with COVID-19 vaccine are crucial in providing awareness on the possible risk factors and signs/symptoms that should raise red flags.
Subject(s)
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / Sinus Thrombosis, Intracranial / Vaccination / Tertiary Care Centers / COVID-19 Vaccines / COVID-19 Type of study: Case report / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: 14760584.2021.1940145

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / Sinus Thrombosis, Intracranial / Vaccination / Tertiary Care Centers / COVID-19 Vaccines / COVID-19 Type of study: Case report / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: 14760584.2021.1940145