Your browser doesn't support javascript.
Infectious disease mRNA vaccines and a review on epitope prediction for vaccine design.
Cai, Xinhui; Li, Jiao Jiao; Liu, Tao; Brian, Oliver; Li, Jinyan.
  • Cai X; Data Science Institute, Faculty of Engineering & IT, University of Technology Sydney, 15 Broadway, Ultimo, 2007, New South Wales, Australia.
  • Li JJ; School of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, 15 Broadway, Ultimo, 2007, New South Wales, Australia.
  • Liu T; School of Life Sciences, Faculty of Science, University of Technology Sydney, 15 Broadway, Ultimo, 2007, New South Wales, Australia.
  • Brian O; Children's Cancer Institute Australia, University of New South Wales Sydney, Children's Cancer Institute Australia, Randwick, Sydney, 2031, New South Wales, Australia.
  • Li J; Data Science Institute, Faculty of Engineering & IT, University of Technology Sydney, 15 Broadway, Ultimo, 2007, New South Wales, Australia.
Brief Funct Genomics ; 20(5): 289-303, 2021 09 11.
Article in English | MEDLINE | ID: covidwho-1258749
ABSTRACT
Messenger RNA (mRNA) vaccines have recently emerged as a new type of vaccine technology, showing strong potential to combat the COVID-19 pandemic. In addition to SARS-CoV-2 which caused the pandemic, mRNA vaccines have been developed and tested to prevent infectious diseases caused by other viruses such as Zika virus, the dengue virus, the respiratory syncytial virus, influenza H7N9 and Flavivirus. Interestingly, mRNA vaccines may also be useful for preventing non-infectious diseases such as diabetes and cancer. This review summarises the current progresses of mRNA vaccines designed for a range of diseases including COVID-19. As epitope study is a primary component in the in silico design of mRNA vaccines, we also survey on advanced bioinformatics and machine learning algorithms which have been used for epitope prediction, and review on user-friendly software tools available for this purpose. Finally, we discuss some of the unanswered concerns about mRNA vaccines, such as unknown long-term side effects, and present with our perspectives on future developments in this exciting area.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / RNA, Messenger / Vaccines / Epitopes Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Brief Funct Genomics Year: 2021 Document Type: Article Affiliation country: Bfgp

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / RNA, Messenger / Vaccines / Epitopes Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Brief Funct Genomics Year: 2021 Document Type: Article Affiliation country: Bfgp