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Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure.
Díaz, Franco; Cores, Camila; Atenas, Omar; Rodríguez, Nicolás; Bustos, Raúl; Cruces, Pablo.
  • Díaz F; From the Hospital El Carmen de Maipú, Unidad de Paciente Crítico Pediátrico, Santiago, Chile.
  • Cores C; Red Colaborativa Pediátrica de Latinoamérica (LARed Network), Santiago, Chile.
  • Atenas O; Instituto de Ciencias e Innovación en Medicina (ICIM), Universidad del Desarrollo, Santiago, Chile.
  • Rodríguez N; From the Hospital El Carmen de Maipú, Unidad de Paciente Crítico Pediátrico, Santiago, Chile.
  • Bustos R; Red Colaborativa Pediátrica de Latinoamérica (LARed Network), Santiago, Chile.
  • Cruces P; Hospital El Carmen de Maipú, Unidad de Diálisis, Santiago, Chile.
Pediatr Infect Dis J ; 40(7): e259-e262, 2021 07 01.
Article in English | MEDLINE | ID: covidwho-1258812
ABSTRACT
Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma Exchange / Systemic Inflammatory Response Syndrome / Immunomodulation / COVID-19 / Multiple Organ Failure Type of study: Case report / Prognostic study Limits: Child, preschool / Female / Humans Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2021 Document Type: Article Affiliation country: Inf.0000000000003169

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma Exchange / Systemic Inflammatory Response Syndrome / Immunomodulation / COVID-19 / Multiple Organ Failure Type of study: Case report / Prognostic study Limits: Child, preschool / Female / Humans Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2021 Document Type: Article Affiliation country: Inf.0000000000003169