Histo-blood group A is a risk factor for severe COVID-19.
Transfus Med
; 32(3): 248-251, 2022 Jun.
Article
in English
| MEDLINE | ID: covidwho-1258987
ABSTRACT
OBJECTIVES:
Evaluate the impact of ABO histo-blood group type on COVID-19 severity.BACKGROUND:
ABO histo-blood type has been associated with different outcomes in infectious diseases. It has also shown a higher proportion of type A patients with SARS-CoV-2. In this observational study, extracted from an ongoing clinical trial on the efficacy of convalescent plasma transfused in COVID-19 patients, we describe the impact of ABO blood type on the risk of developing severe COVID-19. MATERIALS ANDMETHODS:
Seventy-two consecutive patients (37 type A, 23 type O, 11 type B, 1 type AB) with severe (respiratory failure) COVID-19 were included. Control group was composed of 160 individuals randomly selected from the same populational basis.RESULTS:
Blood group A was overrepresented (51.39%) in the patient group in relation to the control group (30%), whereas blood group O was less represented (31.94%) in patient than in control group (48%). Odds ratio (A vs. O) was 2.581 (1.381-4.817), CI 95%; p = 0.004. Also, blood group A patients appeared to have more severe disease, given by the scores of the Sequential Organ Failure Assessment and Simplified Acute Physiologic Score 3 (p = 0.036 and p = 0.058, respectively).CONCLUSION:
Histo-blood type A is associated with a higher risk of developing severe COVID-19 in relation to blood type O.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
Transfus Med
Journal subject:
Hematology
Year:
2022
Document Type:
Article
Affiliation country:
Tme.12796
Similar
MEDLINE
...
LILACS
LIS