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COVID-19 in CKD Patients: Lessons from 553 CKD Patients with Biopsy-Proven Kidney Disease.
Román, Juan León; García-Carro, Clara; Agraz, Irene; Toapanta, Nestor; Vergara, Ander; Gabaldón, Alejandra; Torres, Irina; Bury, Roxana; Baldallo, Cinthia; Serón, Daniel; Soler, María José.
  • Román JL; Department of Nephrology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • García-Carro C; Department of Nephrology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Agraz I; Department of Nephrology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Toapanta N; Department of Nephrology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Vergara A; Department of Nephrology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Gabaldón A; Vall d'Hebron Research Institute (VHIR), Nephrology Department, Nephrology Research Group, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Torres I; Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Bury R; Department of Nephrology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Baldallo C; Department of Nephrology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Serón D; Department of Nephrology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Soler MJ; Department of Nephrology, Vall d'Hebron University Hospital, Barcelona, Spain.
Kidney Blood Press Res ; 46(4): 452-459, 2021.
Article in English | MEDLINE | ID: covidwho-1259042
ABSTRACT

INTRODUCTION:

Chronic kidney disease (CKD) patients infected with COVID-19 are at risk of serious complications such as hospitalization and death. The prognosis and lethality of COVID-19 infection in patients with established kidney disease has not been widely studied.

METHODS:

Data included patients who underwent kidney biopsy at the Vall d'Hebron Hospital between January 2013 and February 2020 with COVID-19 diagnosis during the period from March 1 to May 15, 2020.

RESULTS:

Thirty-nine (7%) patients were diagnosed with COVID-19 infection. Mean age was 63 ± 15 years and 48.7% were male. Hypertension was present in 79.5%, CKD without renal replacement therapy in 76.9%, and cardiovascular disease in 64.1%. Nasopharyngeal swab was performed in 26 patients; older (p = 0.01), hypertensive (p = 0.005), and immunosuppressed (p = 0.01) patients, those using RAS-blocking drugs (p = 0.04), and those with gastrointestinal symptoms (p = 0.02) were more likely to be tested for CO-VID-19. Twenty-two patients required hospitalization and 15.4% died. In bivariate analysis, mortality was associated with older age (p = 0.03), cardiovascular disease (p = 0.05), chronic obstructive pulmonary disease (p = 0.05), and low hemoglobin levels (p = 0.006). Adjusted Cox regression showed that low hemoglobin levels at admission had 1.81 greater risk of mortality.

CONCLUSIONS:

Patients with CO-VID-19 infection and kidney disease confirmed by kidney biopsy presented a mortality of 15.4%. Swab test for COVID-19 was more likely to be performed in older, hypertensive, and immunosuppressed patients, those using RAS-blocking drugs, and those with gastrointestinal symptoms. Low hemoglobin is a risk factor for mortality.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renal Insufficiency, Chronic / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Kidney Blood Press Res Journal subject: Nephrology Year: 2021 Document Type: Article Affiliation country: 000515714

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renal Insufficiency, Chronic / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Kidney Blood Press Res Journal subject: Nephrology Year: 2021 Document Type: Article Affiliation country: 000515714