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Do Anti-androgens Have Potential as Therapeutics for COVID-19?
Mauvais-Jarvis, Franck.
  • Mauvais-Jarvis F; Department of Medicine, Section of Endocrinology, Tulane University School of Medicine, New Orleans, LA, USA.
Endocrinology ; 162(8)2021 08 01.
Article in English | MEDLINE | ID: covidwho-1259229
Semantic information from SemMedBD (by NLM)
1. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
2. Androgens INTERACTS_WITH Androgen Receptor
Subject
Androgens
Predicate
INTERACTS_WITH
Object
Androgen Receptor
3. TMPRSS2 gene|TMPRSS2 STIMULATES Androgens
Subject
TMPRSS2 gene|TMPRSS2
Predicate
STIMULATES
Object
Androgens
4. Lung LOCATION_OF TMPRSS2 gene|TMPRSS2
Subject
Lung
Predicate
LOCATION_OF
Object
TMPRSS2 gene|TMPRSS2
5. Androgen Antagonists TREATS COVID-19
Subject
Androgen Antagonists
Predicate
TREATS
Object
COVID-19
6. Antiandrogen therapy TREATS COVID-19
Subject
Antiandrogen therapy
Predicate
TREATS
Object
COVID-19
7. TMPRSS2 gene|TMPRSS2 INTERACTS_WITH Androgen Antagonists
Subject
TMPRSS2 gene|TMPRSS2
Predicate
INTERACTS_WITH
Object
Androgen Antagonists
8. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
9. Androgens INTERACTS_WITH Androgen Receptor
Subject
Androgens
Predicate
INTERACTS_WITH
Object
Androgen Receptor
10. TMPRSS2 gene|TMPRSS2 STIMULATES Androgens
Subject
TMPRSS2 gene|TMPRSS2
Predicate
STIMULATES
Object
Androgens
11. Lung LOCATION_OF TMPRSS2 gene|TMPRSS2
Subject
Lung
Predicate
LOCATION_OF
Object
TMPRSS2 gene|TMPRSS2
12. Androgen Antagonists TREATS COVID-19
Subject
Androgen Antagonists
Predicate
TREATS
Object
COVID-19
13. Antiandrogen therapy TREATS COVID-19
Subject
Antiandrogen therapy
Predicate
TREATS
Object
COVID-19
14. TMPRSS2 gene|TMPRSS2 INTERACTS_WITH Androgen Antagonists
Subject
TMPRSS2 gene|TMPRSS2
Predicate
INTERACTS_WITH
Object
Androgen Antagonists
ABSTRACT
Coronavirus disease 2019 (COVID-19) is characterized by a gender disparity in severity, with men exhibiting higher hospitalization and mortality rates than women. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, infects cells following recognition and attachment of the viral spike glycoprotein to the angiotensin-converting enzyme 2 transmembrane protein, followed by spike protein cleavage and activation by cell surface transmembrane protease serine 2 (TMPRSS2). In prostate cancer cells, androgen acting on the androgen receptor increases TMPRSS2 expression, which has led to the hypothesis that androgen-dependent expression of TMPRSS2 in the lung may increase men's susceptibility to severe COVID-19 and that, accordingly, suppressing androgen production or action may mitigate COVID-19 severity by reducing SARS-CoV-2 amplification. Several ongoing clinical trials are testing the ability of androgen deprivation therapies or anti-androgens to mitigate COVID-19. This perspective discusses clinical and molecular advances on the rapidly evolving field of androgen receptor (AR) action on cell surface transmembrane protease serine 2 (TMPRSS2) expression and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and the potential effect of anti-androgens on coronavirus disease 2019 (COVID-19) severity in male patients. It discusses limitations of current studies and offers insight for future directions.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Androgen Antagonists Limits: Animals / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: Endocr

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Androgen Antagonists Limits: Animals / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: Endocr