How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System.
Cells
; 10(6)2021 06 07.
Article
in English
| MEDLINE | ID: covidwho-1259432
ABSTRACT
The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response. Viruses encode many factors that interact with the host nuclear transport receptors (NTRs) and the nucleoporins of the nuclear pore complex (NPC) to access the host nucleus. In this review, we discuss the viral factors and the host factors involved in the nuclear import and export of viral components. As nucleocytoplasmic shuttling is vital for the replication of many viruses, we also review several drugs that target the host nuclear transport machinery and discuss their feasibility for use in antiviral treatment.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Replication
/
Cell Nucleus
/
Virus Physiological Phenomena
/
SARS-CoV-2
Limits:
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Cells10061424
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