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Association of Frailty with Adverse Outcomes in Patients with Suspected COVID-19 Infection.
Simon, Noemi R; Jauslin, Andrea S; Rueegg, Marco; Twerenbold, Raphael; Lampart, Maurin; Osswald, Stefan; Bassetti, Stefano; Tschudin-Sutter, Sarah; Siegemund, Martin; Nickel, Christian H; Bingisser, Roland.
  • Simon NR; Emergency Department, University Hospital Basel, 4031 Basel, Switzerland.
  • Jauslin AS; Emergency Department, University Hospital Basel, 4031 Basel, Switzerland.
  • Rueegg M; Emergency Department, University Hospital Basel, 4031 Basel, Switzerland.
  • Twerenbold R; Department of Cardiology, University Hospital Basel, 4031 Basel, Switzerland.
  • Lampart M; Department of Cardiology, University Hospital Basel, 4031 Basel, Switzerland.
  • Osswald S; Department of Cardiology, University Hospital Basel, 4031 Basel, Switzerland.
  • Bassetti S; Department of Internal Medicine, University Hospital Basel, 4031 Basel, Switzerland.
  • Tschudin-Sutter S; Division of Infectious Disease & Hospital Epidemiology, University Hospital Basel, 4031 Basel, Switzerland.
  • Siegemund M; Department of Clinical Research, University of Basel, C/O University Hospital Basel, 4031 Basel, Switzerland.
  • Nickel CH; Department of Clinical Research, University of Basel, C/O University Hospital Basel, 4031 Basel, Switzerland.
  • Bingisser R; Department of Intensive Care, University Hospital Basel, 4031 Basel, Switzerland.
J Clin Med ; 10(11)2021 Jun 02.
Article in English | MEDLINE | ID: covidwho-1259515
ABSTRACT
Older age and frailty are predictors of adverse outcomes in patients with COVID-19. In emergency medicine, patients do not present with the diagnosis, but with suspicion of COVID-19. The aim of this study was to assess the association of frailty and age with death or admission to intensive care in patients with suspected COVID-19. This single-centre prospective cohort study was performed in the Emergency Department of a tertiary care hospital. Patients, 65 years and older, with suspected COVID-19 presenting to the Emergency Department during the first wave of the pandemic were consecutively enrolled. All patients underwent nasopharyngeal SARS-CoV-2 PCR swab tests. Patients with a Clinical Frailty Scale (CFS) > 4, were considered to be frail. Associations between age, gender, frailty, and COVID-19 status with the composite adverse outcome of 30-day-intensive-care-admission and/or 30-day-mortality were tested. In the 372 patients analysed, the median age was 77 years, 154 (41.4%) were women, 44 (11.8%) were COVID-19-positive, and 125 (33.6%) were frail. The worst outcome was seen in frail COVID-19-patients with six (66.7%) adverse outcomes. Frailty (CFS > 4) and COVID-19-positivity were associated with an adverse outcome after adjustment for age and gender (frailty OR 5.01, CI 2.56-10.17, p < 0.001; COVID-19 OR 3.47, CI 1.48-7.89, p = 0.003). Frailty was strongly associated with adverse outcomes and outperformed age as a predictor in emergency patients with suspected COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10112472

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10112472