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Clinical Differences between COVID-19 and a COVID-Like Syndrome.
Di Micco, Pierpaolo; Camporese, Giuseppe; Russo, Vincenzo; Cardillo, Giuseppe; Imbalzano, Egidio; Tufano, Antonella; Bernardi, Enrico; Fontanella, Andrea.
  • Di Micco P; Department of Medicine, Buonconsiglio Fatebenefratelli Hospital of Naples, 80122 Naples, Italy.
  • Camporese G; Unit of Angiology, Department of Cardiac, Thoracic and Vascular Sciences, University Hospital of Padua, 35100 Padua, Italy.
  • Russo V; Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  • Cardillo G; Advanced Biochemistry Unit, Medylab, 80131 Naples, Italy.
  • Imbalzano E; Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.
  • Tufano A; Internal Medicine, Federico II University of Naples, 80131 Naples, Italy.
  • Bernardi E; Department of Emergency and Accident Medicine, Treviso Civil Hospital, 31100 Treviso, Italy.
  • Fontanella A; Department of Medicine, Buonconsiglio Fatebenefratelli Hospital of Naples, 80122 Naples, Italy.
J Clin Med ; 10(11)2021 06 07.
Article in English | MEDLINE | ID: covidwho-1259523
ABSTRACT
COVID-19 is an infection due to SARS-CoV-2; this virus has been identified as the cause of the present pandemic. Several typical characteristics are present in this infection, in particular pneumonia with possible lung failure, but atypical clinical presentations are being described daily by physicians around the world. Ground-glass opacities with pneumonia are the most common and dangerous presentations of the COVID-19 disease, and they are usually associated with positive nasopharyngeal swab (NPS) tests with detectable SARS-CoV-2 viral RNA. Compared to the general population, hospital workers have been at a greater risk of infection ever since the first patients were hospitalized. However, hospital workers have also been reported as having COVID-like symptoms despite repeated negative swab tests but having tested positive for SARS-CoV-2 antibodies with serological tests. We can postulate that a COVID-like syndrome is possible, in particular in hospital workers, that is characterized by symptoms similar to those of COVID-19, but with repeated negative nasopharyngeal swabs. These repeated negative NSPs make the difference in daily clinical management with people that experienced a single false negative nasopharyngeal swab; furthermore, a clear clinical differentiation of these situations is still lacking in the literature. For this reason, here, we report our main findings from a cohort of patients with a COVID-like syndrome compared to a similar group affected by typical COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10112519

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10112519