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Prevalence, Persistence, and Factors Associated with SARS-CoV-2 IgG Seropositivity in a Large Cohort of Healthcare Workers in a Tertiary Care University Hospital in Northern Italy.
Scozzari, Gitana; Costa, Cristina; Migliore, Enrica; Coggiola, Maurizio; Ciccone, Giovannino; Savio, Luigi; Scarmozzino, Antonio; Pira, Enrico; Cassoni, Paola; Galassi, Claudia; Cavallo, Rossana.
  • Scozzari G; Hospital Medical Direction, Ospedale Molinette, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Costa C; Microbiology and Virology Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Migliore E; Clinical Epidemiology Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Coggiola M; Cancer Epidemiology Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Ciccone G; Occupational Medicine Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Savio L; Clinical Epidemiology Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Scarmozzino A; Hospital Medical Direction, Ospedale Molinette, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Pira E; Hospital Medical Direction, Ospedale Molinette, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Cassoni P; Occupational Medicine Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Galassi C; Department of Medical Sciences, Pathology Unit, University of Turin, 10126 Turin, Italy.
  • Cavallo R; Clinical Epidemiology Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • The Collaborative Group; Microbiology and Virology Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
Viruses ; 13(6)2021 06 03.
Article in English | MEDLINE | ID: covidwho-1259623
ABSTRACT
This observational study evaluated SARS-CoV-2 IgG seroprevalence and related clinical, demographic, and occupational factors among workers at the largest tertiary care University-Hospital of Northwestern Italy and the University of Turin after the first pandemic wave of March-April 2020. Overall, about 10,000 individuals were tested; seropositive subjects were retested after 5 months to evaluate antibodies waning. Among 8769 hospital workers, seroprevalence was 7.6%, without significant differences related to job profile; among 1185 University workers, 3.3%. Self-reporting of COVID-19 suspected symptoms was significantly associated with positivity (Odds Ratio (OR) 2.07, 95%CI 1.76-2.44), although 27% of seropositive subjects reported no previous symptom. At multivariable analysis, contacts at work resulted in an increased risk of 69%, or 24% for working in a COVID ward; contacts in the household evidenced the highest risk, up to more than five-fold (OR 5.31, 95%CI 4.12-6.85). Compared to never smokers, being active smokers was inversely associated with seroprevalence (OR 0.60, 95%CI 0.48-0.76). After 5 months, 85% of previously positive subjects still tested positive. The frequency of SARS-COV-2 infection among Health Care Workers was comparable with that observed in surveys performed in Northern Italy and Europe after the first pandemic wave. This study confirms that infection frequently occurred as asymptomatic and underlines the importance of household exposure, seroprevalence (OR 0.60, 95%CI 0.48-0.76).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Health Personnel / Tertiary Care Centers / COVID-19 / Antibodies, Viral Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: V13061064

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Health Personnel / Tertiary Care Centers / COVID-19 / Antibodies, Viral Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: V13061064