Low-Grade Endotoxemia and Thrombosis in COVID-19.
Clin Transl Gastroenterol
; 12(6): e00348, 2021 06 04.
Article
in English
| MEDLINE | ID: covidwho-1259760
ABSTRACT
INTRODUCTION:
Patients with community-acquired pneumonia display enhanced levels of lipopolysaccharides (LPS) compared with controls, suggesting that low-grade endotoxemia may be implicated in vascular disturbances. It is unknown whether this occurs in patients with coronavirus 2019 (COVID-19) and its impact on thrombotic complications.METHODS:
We measured serum levels of zonulin, a marker of gut permeability, LPS, and D-dimer in 81 patients with COVID-19 and 81 healthy subjects; the occurrence of thrombotic events in COVID-19 during the intrahospital stay was registered.RESULTS:
Serum LPS and zonulin were higher in patients with COVID-19 than in control subjects and, in COVID-19, significantly correlated (R = 0.513; P < 0.001). Among the 81 patients with COVID-19, 11 (14%) experienced thrombotic events in the arterial (n = 5) and venous circulation (n = 6) during a median follow-up of 18 days (interquartile range 11-27 days). A logistic regression analysis showed that LPS (P = 0.024) and D-dimer (P = 0.041) independently predicted thrombotic events.DISCUSSION:
The study reports that low-grade endotoxemia is detectable in patients with COVID-19 and is associated with thrombotic events. The coexistence of low-grade endotoxemia with enhanced levels of zonulin may suggest enhanced gut permeability as an underlying mechanism.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Protein Precursors
/
Thrombosis
/
Haptoglobins
/
Endotoxemia
/
SARS-CoV-2
/
COVID-19
/
Intestinal Mucosa
Type of study:
Cohort study
/
Diagnostic study
/
Prognostic study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Clin Transl Gastroenterol
Year:
2021
Document Type:
Article
Affiliation country:
Ctg.0000000000000348
Similar
MEDLINE
...
LILACS
LIS