An Impaired Inflammatory and Innate Immune Response in COVID-19.
Mol Cells
; 44(6): 384-391, 2021 Jun 30.
Article
in English
| MEDLINE | ID: covidwho-1259762
ABSTRACT
The recent appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people around the world and caused a global pandemic of coronavirus disease 2019 (COVID-19). It has been suggested that uncontrolled, exaggerated inflammation contributes to the adverse outcomes of COVID-19. In this review, we summarize our current understanding of the innate immune response elicited by SARS-CoV-2 infection and the hyperinflammation that contributes to disease severity and death. We also discuss the immunological determinants behind COVID-19 severity and propose a rationale for the underlying mechanisms.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Severe Acute Respiratory Syndrome
/
Host-Pathogen Interactions
/
Cytokine Release Syndrome
/
SARS-CoV-2
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Mol Cells
Journal subject:
Molecular Biology
Year:
2021
Document Type:
Article
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