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Antibody response in COVID-19 patients with and without re-positive RT-PCR results during the convalescent phase.
Peng, Jing; Liu, Zhi-Yong; Yu, Xiao-Juan; Chen, Xiao-Yan; Zhang, Kai; Liu, Yi; Su, Ying-Ying; Sun, Chang-Qing.
  • Peng J; Shenzhen Sami Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Liu ZY; Shenzhen Sami Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Yu XJ; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiang'an South Road, Xiamen,
  • Chen XY; Shenzhen Sami Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Zhang K; Shenzhen Sami Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Liu Y; Shenzhen Sami Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Su YY; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiang'an South Road, Xiamen,
  • Sun CQ; Shenzhen Sami Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China. sunchangqing@ssmc-sz.com.
Arch Virol ; 166(8): 2299-2303, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1260595
ABSTRACT
Nucleic acid testing and antibody testing data from 143 recovered COVID-19 patients during the convalescent phase were retrospectively analyzed. A total of 23 (16.1%) recovered patients re-tested positive for SARS-CoV-2 RNA by RT-PCR. Three months after symptom onset, 100% and 99.3% of the patients remained positive for total and IgG antibodies, and the antibody levels remained high. IgM antibodies declined rapidly, with a median time to seroconversion of 67 (95% CI 59, 75) days after onset. Approximately 25% of patients were seronegative for IgA antibodies at three months after onset. There was no statistically significant difference in antibody kinetics between patients with and without re-positive RT-PCR results during the convalescent phase.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Convalescence / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Observational study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Arch Virol Year: 2021 Document Type: Article Affiliation country: S00705-021-05132-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Convalescence / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Observational study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Arch Virol Year: 2021 Document Type: Article Affiliation country: S00705-021-05132-9