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Inflammatory Response Leads to Neuronal Death in Human Post-Mortem Cerebral Cortex in Patients with COVID-19.
Boroujeni, Mahdi Eskandarian; Simani, Leila; Bluyssen, Hans A R; Samadikhah, Hamid Reza; Zamanlui Benisi, Soheila; Hassani, Sanaz; Akbari Dilmaghani, Nader; Fathi, Mobina; Vakili, Kimia; Mahmoudiasl, Gholam-Reza; Abbaszadeh, Hojjat Allah; Hassani Moghaddam, Meysam; Abdollahifar, Mohammad-Amin; Aliaghaei, Abbas.
  • Boroujeni ME; Laboratory of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan 61-614, Poland.
  • Simani L; Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1333635445, Iran.
  • Bluyssen HAR; Laboratory of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan 61-614, Poland.
  • Samadikhah HR; Department of Biology, Faculty of Sciences, Central Tehran Branch, Islamic Azad University, Tehran 13185/768, Iran.
  • Zamanlui Benisi S; Stem Cell Research Center, Tissue Engineering and Regenerative Medicine Institute, Central Tehran Branch, Islamic Azad University, Tehran 13185/768, Iran.
  • Hassani S; Laboratory of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan 61-614, Poland.
  • Akbari Dilmaghani N; Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1333635445, Iran.
  • Fathi M; Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19857-17443, Iran.
  • Vakili K; Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19857-17443, Iran.
  • Mahmoudiasl GR; Legal Medicine Organization, Legal Medicine Research Center, Tehran 1114795113, Iran.
  • Abbaszadeh HA; Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran 19857-17443, Iran.
  • Hassani Moghaddam M; Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran 19857-17443, Iran.
  • Abdollahifar MA; Department of Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19857-17443, Iran.
  • Aliaghaei A; Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran.
ACS Chem Neurosci ; 12(12): 2143-2150, 2021 06 16.
Article in English | MEDLINE | ID: covidwho-1260918
ABSTRACT
The recent coronavirus disease of 2019 (COVID-19) pandemic has adversely affected people worldwide. A growing body of literature suggests the neurological complications and manifestations in response to COVID-19 infection. Herein, we explored the inflammatory and immune responses in the post-mortem cerebral cortex of patients with severe COVID-19. The participants comprised three patients diagnosed with severe COVID-19 from March 26, 2020, to April 17, 2020, and three control patients. Our findings demonstrated a surge in the number of reactive astrocytes and activated microglia, as well as low levels of glutathione along with the upregulation of inflammation- and immune-related genes IL1B, IL6, IFITM, MX1, and OAS2 in the COVID-19 group. Overall, the data imply that oxidative stress may invoke a glial-mediated neuroinflammation, which ultimately leads to neuronal cell death in the cerebral cortex of COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: English Journal: ACS Chem Neurosci Year: 2021 Document Type: Article Affiliation country: Acschemneuro.1c00111

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: English Journal: ACS Chem Neurosci Year: 2021 Document Type: Article Affiliation country: Acschemneuro.1c00111