Improving clinical paediatric research and learning from COVID-19: recommendations by the Conect4Children expert advice group.
Pediatr Res
; 91(5): 1069-1077, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1260928
ABSTRACT
BACKGROUND:
The COVID-19 pandemic has had a devastating impact on multiple aspects of healthcare, but has also triggered new ways of working, stimulated novel approaches in clinical research and reinforced the value of previous innovations. Conect4children (c4c, www.conect4children.org ) is a large collaborative European network to facilitate the development of new medicines for paediatric populations, and is made up of 35 academic and 10 industry partners from 20 European countries, more than 50 third parties, and around 500 affiliated partners.METHODS:
We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equity.FINDINGS:
We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equityWe provide examples of research innovation, and follow this with recommendations to improve the efficiency of future trials, drawing on industry perspectives, regulatory considerations, infrastructure requirements and parent-patient-public involvement. We end with a comment on progress made towards greater international harmonisation of paediatric research and how lessons learned from COVID-19 studies might assist in further improvements in this important area.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pediatrics
/
COVID-19
Type of study:
Prognostic study
Limits:
Child
/
Humans
Country/Region as subject:
Europa
Language:
English
Journal:
Pediatr Res
Year:
2022
Document Type:
Article
Affiliation country:
S41390-021-01587-3
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