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The Israeli study of Pfizer BNT162b2 vaccine in pregnancy: considering maternal and neonatal benefits.
Burd, Irina; Kino, Tomoshige; Segars, James.
  • Burd I; Integrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Kino T; Laboratory of Molecular and Genomic Endocrinology, Sidra Medicine, Doha, Qatar.
  • Segars J; Division of Reproductive Sciences, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Clin Invest ; 131(13)2021 07 01.
Article in English | MEDLINE | ID: covidwho-1261225
ABSTRACT
Pregnant patients with COVID-19 are more likely to require intensive care and die compared with noninfected pregnant women. While the consequences of COVID-19 disease in pregnancy prompted many health care organizations to support vaccination in pregnancy, vaccine effects for mother and infant remained unclear. In this issue of the JCI, Beharier and Mayo et al. explored maternal and neonatal responses to the Pfizer BNT162b2 SARS-CoV-2 mRNA vaccine. The authors examined blood samples from women and cord blood of neonates following childbirth. Samples were stratified into three groups vaccine recipients, unvaccinated participants with past positive SARS-CoV-2 test, and unvaccinated participants without prior infection. Vaccinated mothers and mothers with previous infection generated and transferred protective IgG antibodies across the placenta. This study provides evidence to support the safety and efficacy of COVID-19 vaccination in pregnancy with protection to the neonate against infection, outlining clear vaccine benefits for both maternal and child health.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Child / Female / Humans / Infant, Newborn / Pregnancy Language: English Year: 2021 Document Type: Article Affiliation country: Jci150790

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Child / Female / Humans / Infant, Newborn / Pregnancy Language: English Year: 2021 Document Type: Article Affiliation country: Jci150790