Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany.

Schwarz, Tatjana; Tober-Lau, Pinkus; Hillus, David; Helbig, Elisa T; Lippert, Lena J; Thibeault, Charlotte; Koch, Willi; Landgraf, Irmgard; Michel, Janine; Bergfeld, Leon; Niemeyer, Daniela; Mühlemann, Barbara; Conrad, Claudia; Dang-Heine, Chantip; Kasper, Stefanie; Münn, Friederike; Kappert, Kai; Nitsche, Andreas; Tauber, Rudolf; Schmidt, Sein; Kopankiewicz, Piotr; Bias, Harald; Seybold, Joachim; von Kalle, Christof; Jones, Terry C; Suttorp, Norbert; Drosten, Christian; Sander, Leif Erik; Corman, Victor M; Kurth, Florian

Schwarz, Tatjana; Tober-Lau, Pinkus; Hillus, David; Helbig, Elisa T; Lippert, Lena J; Thibeault, Charlotte; Koch, Willi; Landgraf, Irmgard; Michel, Janine; Bergfeld, Leon; Niemeyer, Daniela; Mühlemann, Barbara; Conrad, Claudia; Dang-Heine, Chantip; Kasper, Stefanie; Münn, Friederike; Kappert, Kai; Nitsche, Andreas; Tauber, Rudolf; Schmidt, Sein; Kopankiewicz, Piotr; Bias, Harald; Seybold, Joachim; von Kalle, Christof; Jones, Terry C; Suttorp, Norbert; Drosten, Christian; Sander, Leif Erik; Corman, Victor M; Kurth, Florian.

Emerg Infect Dis ; 27(8): 2174-2178, 2021 08.

Article in English | MEDLINE | ID: covidwho-1261342

ABSTRACT

ABSTRACT

We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.

Subject(s)

COVID-19; Adult; Aged; Aged, 80 and over; BNT162 Vaccine; COVID-19 Vaccines; Germany/epidemiology; Humans; SARS-CoV-2; T-Lymphocytes; Vaccination

Keywords

B cell; Berlin; COVID-19; Germany; SARS-CoV-2; T cell; antibody; coronavirus disease; immunity; mRNA; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine; viruses; zoonoses

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study Topics: Vaccines Limits: Adult / Aged / Humans Country/Region as subject: Europa Language: English Journal: Emerg Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article

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