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Optimizing vaccine allocation for COVID-19 vaccines shows the potential role of single-dose vaccination.
Matrajt, Laura; Eaton, Julia; Leung, Tiffany; Dimitrov, Dobromir; Schiffer, Joshua T; Swan, David A; Janes, Holly.
  • Matrajt L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. laurama@fredhutch.org.
  • Eaton J; School of Interdisciplinary Arts and Sciences, University of Washington, Tacoma, WA, USA.
  • Leung T; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Dimitrov D; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Schiffer JT; Department of Applied Mathematics, University of Washington, Seattle, WA, USA.
  • Swan DA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Janes H; Department of Medicine, University of Washington, Seattle, WA, USA.
Nat Commun ; 12(1): 3449, 2021 06 08.
Article in English | MEDLINE | ID: covidwho-1262000
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ABSTRACT
Most COVID-19 vaccines require two doses, however with limited vaccine supply, policymakers are considering single-dose vaccination as an alternative strategy. Using a mathematical model combined with optimization algorithms, we determined optimal allocation strategies with one and two doses of vaccine under various degrees of viral transmission. Under low transmission, we show that the optimal allocation of vaccine vitally depends on the single-dose efficacy. With high single-dose efficacy, single-dose vaccination is optimal, preventing up to 22% more deaths than a strategy prioritizing two-dose vaccination for older adults. With low or moderate single-dose efficacy, mixed vaccination campaigns with complete coverage of older adults are optimal. However, with modest or high transmission, vaccinating older adults first with two doses is best, preventing up to 41% more deaths than a single-dose vaccination given across all adult populations. Our work suggests that it is imperative to determine the efficacy and durability of single-dose vaccines, as mixed or single-dose vaccination campaigns may have the potential to contain the pandemic much more quickly.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 Vaccines / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-23761-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 Vaccines / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-23761-1